Can women's menopause be indefinitely postponed? The mathematical model provides a positive answer. A new model developed by mathematicians at the University of Utah in the United States shows that by transplanting a woman's own ovarian tissue back into the body, the onset of menopause may be indefinitely delayed. This technology has been successfully used to restore the fertility of cancer patients, and the research paper was recently published in the American Journal of Obstetrics and Gynecology. When a girl is born, her ovaries have about a million tiny structures called primordial follicles, each containing an egg cell. As girls grow into adults, most follicles will die, and only one follicle per month can survive and ovulate. When there are few remaining primordial follicles, women will enter menopause. Researchers say that people hope to postpone menopause, largely for the sake of childbirth; But there are also views that believe that normal ovarian function is beneficial for women's health. This is because it has been found that menopause is associated with many health issues, such as cardiovascular disease, bone density issues, obesity, etc. Maintaining ovarian function for a longer period of time may delay or even prevent the occurrence of these problems. In the latest interdisciplinary study, ovarian biologists from the University of Colorado School of Medicine, professors of statistics and data science from Yale University, and reproductive science professors from Yale Medical School worked together to answer an unanswered question: how long can menopause be delayed? For this, the research team used mathematical modeling. Based on key data points, they developed a model similar to an online calculator. The model prediction results show that a low-temperature preservation and transplantation technique for ovarian tissue can significantly delay menopause. For example, for a woman with a median ovarian reserve, if 25% of her ovarian cortex is cryopreserved at the age of 25, and the survival rate of transplanted follicles reaches 40%, her menopause can be delayed by about 11.8 years; If the survival rate of follicles can reach 80%, it can be delayed by 15.5 years. By repeatedly transplanting the same number of tissues, the onset of menopause can be further delayed. Researchers suggest that new technologies can also be used to improve the survival rate of follicles. If it can increase to 80% and undergo 3-6 more surgeries, menopause may be delayed by 47 years. This means that for women under the age of 30, it is possible to completely prevent the onset of menopause. (Lai Xin She)