The winter weather turns cold, and dermatology clinics often queue up in long lines. Ms. Li (pseudonym), who is deeply troubled by atopic dermatitis, is one of them. She usually has less colds and fever, and this winter she began to experience unbearable itching and rash on her body. Her skin condition has also worsened, and it turns out that atopic dermatitis has occurred again. The recurring itching caused her poor sleep and emotional depression, which began to affect her daily work and made this New Year not peaceful. Regarding this, Associate Professor Zhao Zuotao from the Department of Dermatology at Peking University First Hospital reminds that atopic dermatitis has four major characteristics: chronic, inflammatory, itchy, and recurrent. In winter, the weather is cold and dry, and the temperature repeatedly reaches new lows. External environmental stimuli can easily cause the aggravation and recurrence of atopic dermatitis in patients, and it is urgent to do a good job in long-term, standardized disease management, and daily skin care. Atopic dermatitis is considered the "number one disease" in dermatology. It is a type 2 inflammatory disease characterized by dryness, itching, and recurrent chronic eczema like lesions, often diagnosed as eczema in the past. In recent years, the incidence rate of atopic dermatitis has been rising, with the incidence rate of 5-10% in adults and 10-15% in children. This disease cannot be ignored. Water deficiency and impaired skin barrier function. In winter, atopic dermatitis is more likely to worsen and recur. This is because the moisture content of the human skin is inherently lower than that of the general population. Dry air and low humidity in winter may exacerbate water deficiency and even accelerate the release of moisture from the skin into the air, leading to impaired skin barrier function. In addition, factors such as inadequate body care and inadequate moisturizing can easily lead to a resurgence of atopic dermatitis. The underlying pathogenesis is "inflammation". The most obvious daily experience for patients with atopic dermatitis is "itching", an unbearable itching. However, "itching" is only a symptom, and the deeper pathogenesis is "inflammation", medically known as type 2 inflammation. Among them, two cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), play a key role and are important "switches" that induce inflammatory reactions. Therefore, identifying the root cause of the disease and treating it is crucial. "Zhao Zuotao explained," If not effectively controlled, the disease is highly likely to recur, and patients may suffer from severe itching, skin lesions, sleep interruptions, and other disease burdens. Normal work and study rhythms are disrupted. "Social scenes can also be limited, seriously affecting their physical and mental health and quality of life. In the future, the risk of coexisting with allergic rhinitis, asthma, and other types of inflammation is high, while atopic dermatitis is only the" first stop "of type 2 inflammation driven diseases. Early onset of atopic dermatitis will increase the risk of coexisting with other types of inflammation such as allergic rhinitis and asthma in the future. Zhao Zuotao added, "Therefore, the control of atopic dermatitis is particularly important for adolescents, infants and young children. It not only requires long-term treatment, but also timely treatment, vigilance against 'multiple diseases with one lesion', and avoiding greater burden at critical moments of growth, development, learning, and psychological growth." Patients have misconceptions about the disease. In the process of frequent recurrence of atopic dermatitis, there are environmental "external factors" as well as patient "internal factors". Currently, many patients still have misconceptions about the disease, and there is a need for standardized treatment