When it comes to the negative effects of sugary drinks and juice on health, the first thing that comes to mind is that drinking too much can lead to weight gain, but in reality, these two drinks also have another negative effect - increasing uric acid. The results of the National Health and Nutrition Survey in the United States show that beverages with high fructose content (whether artificially synthesized or natural pure fruit juice) and the intake of nutritional fructose are both associated with elevated blood uric acid levels. The fact that they have gained weight is probably well-known to everyone - it contains a large amount of free sugar, which is equivalent to drinking sugar water directly, otherwise it would not have the reputation of "Fat House Happy Water". If you add one or two bottles of sugary drinks and/or fruit juice with sufficient energy intake throughout the day, the fattening effect is absolutely unquestionable. So, why can sugary beverages cause uric acid abnormalities? Why are they juice and sugary drinks? Firstly, being overweight or obese itself increases the risk of cardiovascular disease and hyperuricemia. Secondly, these two types of fatty water have a particularly unfriendly commonality towards uric acid: either they contain a large amount of free fructose, or they are metabolized by the human body to produce a large amount of fructose. In short, it will "input" a large amount of fructose into the body. Fructose can add insult to injury to blood uric acid levels! The effect of fructose on blood uric acid levels comes from two aspects: promoting the generation of uric acid and reducing its excretion. To use a vivid metaphor, it is like opening and throttling a reservoir, accelerating the discharge of water into the pool while limiting the flow at the outlet, causing the water level in the pool to rise. The sugar added to sugary beverages is often fructose, sucrose, fructose syrup, high fructose corn syrup, conversion syrup, etc. Except for fructose itself, other carbohydrate metabolites include fructose. Taking sucrose as an example, 1 molecule of sucrose is processed by the body, and the hydrolysis product is 1 molecule of glucose+1 molecule of fructose. The main sugar in 100% pure fruit juice is also fructose, in addition to some glucose and sucrose. If it is not 100% pure fruit juice, the additional added sugar is basically the same as the above. In short, as long as we pour ourselves tons of happy water, it will make our liver receive a large amount of fructose in a short period of time. How does fructose affect blood uric acid levels? Similarly, glucose cannot induce uric acid production like fructose. The reason is that the fructose metabolism pathway is very, very "special", and its metabolic process is "unmanaged", unlike glucose metabolism, which is "limited by speed" (referred to as speed limit) by the human body. In the process of human evolution, in order to ensure that the body surviving in harsh environments in the wild does not quickly run out of "fuel" (energy supply substances), a unique energy protection mechanism has been formed, which limits the rate of glucose metabolism. The purpose is to enable the most economical and affordable glucose to continuously provide us with energy, so as to prevent us from fainting due to hypoglycemia and even threatening our lives before we have done anything. Fructose, on the other hand, does not have a rate limiting device (we call it a "rate limiting enzyme") for its metabolism. So, guess what happens when there's a lot of fructose concentrated in your stomach all at once? When the intake of fructose is moderate, the small intestine has sufficient capacity to metabolize it. Let's first understand which organ in the body is the main organ