As a "experimental field" for reform and opening up, in recent years, Shenzhen has continuously explored the "new paradigm of basic research" and found a new path of independent innovation and development with Shenzhen characteristics. Zhong Hai, Deputy Director of the Shenzhen Science and Technology Innovation Committee, stated that basic research is the source of innovation. The exploration and innovation at the source are more uncertain and require long-term focus. Therefore, establishing a diversified basic research guarantee system from top to bottom is particularly crucial. It is understood that Shenzhen, led by top-level design, has launched a series of "combination fists" such as institutional innovation, platform building, strengthening achievement transformation, and increasing talent cultivation, building a comprehensive ecological chain of technological innovation from multiple dimensions, igniting Shenzhen's original innovation power. Since 2019, Shenzhen has successively issued the "Implementation Measures for Strengthening Basic Scientific Research in Shenzhen", issued the "Deep Research" plan for implementing basic research, clarified the key development of 20 strategic emerging industry clusters and 8 future industries, and focused on promoting basic research in 12 fields. From 2020 to 2022, the financial investment in basic research and applied basic research in Shenzhen reached 15 billion yuan. Relying on the advantages of industrial clusters, we will vigorously promote the "talent introduction" work. Shenzhen has established a two-way flow system for scientific and technological personnel, and established a sound mechanism for early detection, early selection, and long-term stable support of young scientific and technological talents. In 2022, Shenzhen will add 17 full-time academicians, totaling 91; Introduce over 200 high-level innovation and entrepreneurship teams from overseas. From 2017 to 2022, the number of national funded projects for Shenzhen's technological talents increased from 619 to 1400, and the funding increased from 313 million yuan to 770 million yuan. With the continuous increase in investment in basic research, a series of major technological infrastructure has begun to take shape, and the basic research platform system is becoming increasingly perfect. As of 2022, Shenzhen has built a total of 3223 various innovation carriers, including 153 at the national level and 1278 at the provincial level. Among them, Guangming Science City focuses on the three major scientific fields of information, life, and new materials, with a centralized layout of 9 major scientific installations, 11 cutting-edge cross research platforms, 2 laboratories, and 2 research-oriented universities, totaling 24 major scientific and technological innovation carriers. Zhang Dongdong, Deputy Director of the Development and Reform Bureau of Guangming District, Shenzhen, stated that as of now, the Guangming Science City has invested over 50 billion yuan in construction funds. Among them, the two major scientific facilities of synthetic biology research, brain analysis, and brain simulation have been fully completed, and equipment is being promoted and will soon be put into use. In the process of technological innovation, bridging the chain of achievement transformation is the key to completing basic research from "0" to "1". Shenzhen is promoting the formation of a new technology achievement transformation model that spans the boundaries of traditional quadrants, using flexible and diverse methods to build a full chain innovation ecosystem. Overall, Shenzhen's layout and practices in the field of basic research are demand-oriented and market-oriented, building a multi-dimensional collaborative innovation chain that includes institutional supply, funding guarantee, talent supply, and diversified transformation. "said Wu Delin, Secretary of the Party Committee of Harbin Institute of Technology (Shenzhen) and Professor of the School of Economics and Management. In this process, it is still necessary to further strengthen key core technology research, Optimize the investment efficiency of scientific research funds