The rounder the heart, the higher the risk of disease

2023-04-06

Do you want to know if you are at risk of developing both atrial fibrillation and cardiomyopathy? Researchers from the Smit Heart Research Institute of West Dassanai Medical Center in the United States found that people with baseball shaped round hearts are more likely to have the two heart diseases mentioned above in the future than people with hearts that are longer in shape and more like traditional hearts. The relevant paper was published on March 29th in the journal "Medicine" under the umbrella of "Cell". Researchers use deep learning and advanced imaging analysis to study the genetics of heart structure. The results showed that people with a circular heart were 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy. Researchers analyzed the cardiac magnetic resonance images of 38897 healthy individuals from the UK Biobank and determined this risk. Using the same database, the researchers used computational models to identify heart genetic marker associated with these heart diseases. Through genetic research on the circular heart, they identified four genes associated with cardiomyopathy: PLN, ANGPT1, PDZRN3, and HLADR/DQ. The first three of these genes are also more associated with the risk of developing atrial fibrillation. Experts from Smit Heart Research Institute said that a person's heart shape will change over time, usually becoming more rounded, especially after a major event such as a heart attack. Christine M. Albert, one of the study authors and head of the Department of Cardiology at the Smit Heart Institute, said that the change in the shape of the heart may be the first sign of disease. Understanding how the heart changes when facing diseases, coupled with existing more reliable and intuitive imaging support, is a key step in preventing two common heart diseases. (New News Agency)

Edit:Niexiaoqian    Responsible editor:Guanguan

Source:People.cn

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