On December 5, the reporter of Science and Technology Daily learned from the Department of Science and Technology of Fujian Province and Xiamen University that a few days ago, the nasal spray influenza virus vector COVID-19 vaccine (hereinafter referred to as "nasal spray COVID-19 vaccine"), an emergency scientific research achievement for epidemic prevention and control supported by the Department, was proposed by the National Health Commission and approved for emergency use by the State Food and Drug Administration. Research data show that the vaccine has good protective effect and safety against symptomatic infections caused by Omicron strain. This "nasal COVID-19 vaccine", led by Xiamen University and jointly developed by the University of Hong Kong and Beijing Wantai Biological Pharmaceutical Co., Ltd., is one of the five technical routes for China to deploy COVID-19 vaccine to tackle emergency problems, and is also the first "nasal COVID-19 vaccine" approved for clinical trials in the world. It is reported that influenza virus has the characteristics of anatomical distribution of susceptible cells in the whole respiratory tract starting from the nasal cavity and highly overlapping with COVID-19 (especially the variant strain of Omicron). The vaccine is inoculated by nasal spray, which can form the first immune barrier in the respiratory tract to prevent COVID-19 invasion. It has rapid effect and lasting protection, and has outstanding broad-spectrum protection advantages for various mutants, including Omikron. Innovation mechanism, Rapid emergency response to scientific research has achieved results The coronavirus vaccine team fully mobilized the scientific and technological resources and forces of all parties in the province to organize the scientific research of COVID-19 vaccine. " Chen Qiuli, director of the Science and Technology Department of Fujian Province, said. To this end, the Department of Science and Technology of Fujian Province quickly selected the advantageous scientific research units, enterprises and experts in the fields of infectious disease prevention and control, virus detection, vaccine research and development in the province, and launched the early nationwide collection of emergency scientific research projects for epidemic disease prevention and control. In terms of vaccine research and development, the focus is on relying on the Xia Ningshao team of the National Research Center for Infectious Disease Diagnostic Reagents and Vaccine Engineering Technology of Xiamen University Two technical routes of genetic engineering recombinant vaccine were adopted to tackle emergency problems. At the same time, adhere to the principle of "urgent need for epidemic situation, short-term effect", "research first, then project establishment", "research while reporting", adopt "special case handling", simplify project establishment procedures, launch and implement the "1+N" project for emergency scientific research on epidemic prevention and control, give full play to the guiding role of scientific and technological innovation funds, and encourage more hard core achievements. Focusing on the outstanding problem of the lack of high-level medical research laboratories, the Department actively integrates into the overall layout of national high-level biosafety laboratories, plans and promotes the construction of Xiamen University's Level III Animal and Biosafety (P3) Laboratory, relying on platforms such as the National Research Center for Infectious Disease Diagnostic Reagents and Vaccine Engineering Technology of Xiamen University. Cooperate together to get through the key links of achievements transformation "In order to speed up the research and development of COVID-19 vaccine and promote the early launch of products, the Science and Technology Department of Fujian Province closely tracks the progress of the project, and fully follows up the project establishment, pre clinical research, application approval documents, and clinical research