Recently, the domestic epidemic situation has undergone new changes, and the number of new cases in some regions has continued to rise. At the critical moment, we must unify our thoughts and make precise decisions. We believe that as long as we continue to adapt to the new characteristics of COVID-19 variation and the new situation of epidemic prevention and control, and scientifically and accurately optimize and refine the prevention and control measures, we will be able to fight well against epidemic. To optimize and improve the prevention and control measures, we must first control the source and cut off the communication channels. At present, multiple subtype variants of COVID-19 are accelerating in the global epidemic, especially Omicron BF 7. The proportion of variant infection increased rapidly, the mode of transmission was more hidden, and the transmission speed was faster. In the face of the epidemic, we must not respond negatively by "lying down". An obvious fact is that there are 267 million people aged 60 and above in China, accounting for 18.9% of the total population. Most elderly people have basic diseases and are the most affected group by the epidemic. In addition, the number of elderly people in China is huge and the impact is wide. Strengthening prevention is still the top priority. To "find and manage" high risk areas, and to control the risk within the minimum range, is a concrete manifestation of "always putting people's life safety and health first". It can be said that the basic work of epidemic prevention and control is to effectively improve the scientific, precise and standardized level of epidemic prevention and control, and scientifically delineate risk areas. To optimize and improve the prevention and control measures, we need to strengthen research and judgment according to time and situation, and optimize measures according to time and place, so that the prevention and control work is more accurate, more effective, and more in line with the requirements of economic and social development and the needs of the people. At present, Guangzhou, Shenzhen, Chongqing and other places have made relevant arrangements respectively, emphasizing the scientific and accurate principle of epidemiological investigation, timely and accurate determination of close contacts, not randomly expanding the scope of close contact screening, and not taking time and space as the criteria for determining close contacts. These measures are more targeted and positive optimization measures taken after the study and judgment of the epidemic situation, indicating that our ability to deal with the epidemic situation is improving, and the prevention and control measures are more scientific and accurate. The pipe should be controlled and the solution should be untied as soon as possible. At present, in many places, we have accurately grasped the policy changes, constantly optimized and adjusted the prevention and control measures according to the time and situation, and promoted the orderly recovery of the people's normal production and life. In this regard, Guangzhou, Kunming, Chongqing, Beijing, Shijiazhuang and other places are making positive attempts. Some places are making efforts to achieve "quick closure, quick release and full solution", effectively saving resources, and trying to reduce the impact of the epidemic on economic and social development and the production and life of the masses, which has received the positive response of the masses. The current epidemic situation requires no relaxation. We should fully understand the complexity, arduous nature and repeatability of the anti epidemic struggle, overcome all difficulties and challenges, and believe in the power of science. We must resolutely implement the decisions and arrangements of the Central Committee of the Communist Party of China (CPC). In accordance with the requirements of preventing epidemics, stabilizing the economy, and ensuring safe development, we should effectively coordinate epidemic prevention and control and economic and social development, maximize the protection of people's lives and health, minimize the impact of epidemics on economic and social development, and quickly maximize the effectiveness of epidemic prevention and control at the lowest social cost. (Outlook New Times)