After more than 70 years of development, Guangdong General Hospital, founded in 1946, has become a large, Grade III, Grade A comprehensive hospital that enjoys a high reputation at home and abroad. In 2018, the hospital was selected as one of the first batch of "high-level construction hospitals" in Guangdong Province, and medical education and research work comprehensively entered the high-speed lane of high-quality development. As the pacesetter in the construction of high-level hospitals in Guangdong Province, how can Guangdong General Hospital aim at the international medical frontier and national medical development strategy, and achieve leapfrog development by virtue of the geographical and talent technology advantages gathered in the Guangdong–Hong Kong–Macao Greater Bay Area? How to explore paths for the reform of public hospitals and promote high-quality development of medical and health work? The reporter of Outlook Newsweek interviewed Yu Xueqing, the president of Guangdong General Hospital (Guangdong Academy of Medical Sciences). "Climbing the peak" of a high-level hospital Outlook: How has Guangdong General Hospital made efforts in discipline construction since Guangdong started the construction of a high-level hospital? Yu Xueqing: Since Guangdong General Hospital was selected as one of the first batch of "high-level construction hospitals", we have concentrated our efforts, determined to "reach the peak", focused on "strengthening the heart, lungs, kidneys, respecting the elderly, and tranquility", and driven the platform and supporting disciplines to flourish with advantageous disciplines. In five years, the cardiovascular disease specialty of Guangdong General Hospital was selected into the National Regional Medical Center for Cardiovascular Diseases jointly built by the CPC Guangdong Provincial Committee; The innovative Sex therapy model of lung cancer has rewritten international and domestic guidelines, and continues to lead the world; Create the world's first smart Peritoneal dialysis center, and the "Guangzhou model" of peritoneal dialysis radiates around the world; At the same time, it has the qualification of heart, lung, liver and kidney transplantation, and the number of Heart transplantation operations remains the third in China, ranking among the top 10 in the world. Guangdong General Hospital is also the supporting unit of Guangdong Institute of Cardiology, Guangdong Institute of Geriatrics and Guangdong Mental Health Center. The Department of Nephrology of Guangdong General Hospital is a national key clinical specialty, both in scale and echelon. After I worked in Guangdong General Hospital, I first established the International Kidney Disease Research Center of Guangdong General Hospital, and then was approved as the Guangdong Hong Kong Joint Laboratory for Immune and Genetic Research on Chronic Nephropathy, further improving the basic research level and strength of the discipline. We have a good team in immunology, pathology, genetics, spatiotemporal Transcriptome, structural biology, etc., and have a great influence in the world. The completed research has also become an important part of international guidelines. At the same time, we also established the world's first smart Peritoneal dialysis center to introduce China's experience, data and models to the world. Outlook: Since the Guangdong General Hospital started the construction of a high-level hospital, how can we achieve significant improvement in various evaluation indicators? Yu Xueqing: Since the start of the construction of a high-level hospital, Guangdong General Hospital has ushered in the fastest development period since its establishment - the ranking of the performance appraisal of the third level public hospitals has been improved by leaps and bounds, and it has remained at the forefront of the country; The number of projects of the National Natural Science Foundation of China doubled, with 100 in 2022, a record high; Approved doctoral program in the first level discipline of clinical medicine; Multiple high-level research results have been published in top international journals such as the New England Journal of Medicine, the British Medical Journal, and Science. The development idea of Guangdong General Hospital is to support the young and middle-aged. The 'zenith' is to keep up with the international advanced level; Standing on the ground