In the afternoon of May 8, the joint prevention and control mechanism of the State Council held a press conference to introduce the prevention and control work after the COVID-19 no longer constitutes a "public health emergency of international concern". 1、 What is the trend of the epidemic after the May Day holiday? Liu Qing, Deputy Director of the Department of Infectious Disease Control and Prevention of the National Bureau of Disease Control and Prevention, introduced that experts believed that the national epidemic reached its lowest level since November 2022 in the first ten days of April this year, due to the objective law of immunity decline over time after vaccination and COVID-19 infection. Recently, the situation began to rise slowly. This change trend is in line with expectations, and is also similar to the law of the fluctuation and prevalence of the global Omikron virus strain. The decline of population immunity is a gradual process, and the overall level of immune protection in China is still relatively high. During the May Day holiday, the gathering and mobility of people have increased, objectively increasing the chances of virus transmission. It is expected that the epidemic in some regions of the country may experience a slight rebound after the May Day holiday, and the number of places where clustered outbreaks occur may increase. However, the possibility of a large-scale epidemic is not high, and it will not have a significant impact on medical treatment and social operations in the short term. 2、 Should we worry about the XBB series variant? Chen Cao, a researcher from the Institute of Viral Diseases of the Chinese Center for Disease Control and Prevention, said that at present, the main epidemic strains of COVID-19 in China have become XBB series variants. Monitoring data shows that in late April, the proportion of XBB series variants in imported cases in China has reached 97.5%, which is basically consistent with the global proportion of XBB series variants; The proportion of XBB series variants in local cases has been continuously increasing since February this year, from 0.2% in mid February to 74.4% in late April. Meanwhile, BA. 5.2, BF. 7, BA. 2 and their sub branches together account for about 25%. However, based on current monitoring data, there is no significant change in pathogenicity between the prevalent variants, including XBB, and the early Omicron subfamilies. 3、 Will the measures of "Class B and Class B management" continue to be implemented? Liang Wannian, the leader of the expert group of the leading group for epidemic response and disposal of the National Health Commission, said that ending the "public health emergencies of international concern" does not mean the end of the COVID-19 epidemic, nor does it mean that there will be no harm from the epidemic, nor does it mean that we will let COVID-19 epidemic go. Mi Feng, spokesman of the National Health Commission, said that at present, the COVID-19 is still changing, the domestic epidemic situation is generally sporadic, and disease hazards still exist. All regions and departments should continue to implement various measures of "Class B and Class B management", while ensuring the health of the people and facilitating their production and life. 4、 What are the considerations for WHO to declare that the COVID-19 epidemic no longer constitutes a "public health emergency of international concern"? Liang Wannian introduced that WHO announced that the COVID-19 epidemic would no longer constitute a "public health emergency of international concern", mainly based on the epidemic situation, virus variation characteristics, population immune barrier and system response capacity building. First, from the perspective of the current epidemic situation, the number of COVID-19 infections, hospitalizations, severe hospitalizations, and deaths reported globally are all at a low level