Colleges and universities are the "guiding force" of the combination of education, science and technology, and talents. We should strengthen systematic thinking, "jump out of education to run education, jump out of science and technology to develop science and technology", promote the deep integration of "talent chain, innovation chain, discipline chain, and industry chain", and contribute scientific and educational wisdom to the high-quality development of the economy and society. The essence of the deep integration of the "four chains" is an innovation ecosystem composed of strong interaction among innovation subjects such as universities, scientific research institutions, enterprises and scientific and technological service institutions. In the "four chains", talent is the first resource, innovation is the first power, discipline is the main channel for talent cultivation and achievement output, and industry is the main battlefield for talent use and achievement transformation. At present, there are still difficulties in the deep integration of the "four chains", such as the phenomenon of mutual disconnection, and the innovation ecology of deep integration has not yet formed; The consciousness and initiative of collaborative innovation of all innovation subjects are not enough. It is recommended that colleges and universities actively connect with other innovation entities, promote the in-depth integration of the "four chains" by coordinating the talent chain and innovation chain, accurately configure the discipline chain and talent chain around the industrial chain and innovation chain, and promote the advanced industrial base and modernization of the industrial chain through the in-depth integration of the "four chains", and further strengthen the advantages of the integrated development of the "four chains". (Outlook New Era)