Liu Cangli, academician of the CAS Member and president of the Chinese Academy of Engineering Physics, insisted on being down-to-earth and starting from reality to strengthen basic research. Scientific researchers should base themselves on the reality of our country, start from the current level of scientific and technological capabilities, and focus on the needs of the country and society to strengthen basic research. To achieve self-reliance and self-reliance in science and technology, we need to overcome each difficult problem. In particular, in the face of major strategic areas and "bottleneck" areas related to development and security, there are still a large number of basic scientific issues to break through behind the engineering and technical issues. They are not necessarily the latest and most eye-catching, but there is an urgent need for someone to peel the cocoon layer by layer, try and improve again and again, and improve a little. The majority of scientific researchers should be down-to-earth and work hard to assume the mission and responsibility of scientific and technological workers in the new era to serve the country and become a powerful country in science and technology. To strengthen basic research, we should protect the enthusiasm of various subjects in the scientific and technological innovation chain and guarantee the efficient connection of all links through scientific and reasonable system design and the creation of a clean and positive environment. Support and encourage down-to-earth, realistic and pragmatic people to sit on the "cold bench", protect and protect the "wall breaker" for ten years, and wait for the flowers to bloom. Fang Fuquan, an academician of the CAS Member and president of Capital Normal University, represents the need for continuous trial and error in solving scientific problems. Basic research is the foundation of major original innovation "from 0 to 1". The rapid development of science and technology has contributed to earth-shaking changes in China's economic and social outlook. At present, China's scientific and technological work is facing major challenges. There are still many "stuck neck" problems in key fields such as chips, "double carbon", and biological breeding. The strength of basic research is still far from the world's scientific and technological power. Basic research has distinctive characteristics. First of all, to do basic research well, we should be good at raising good questions. These problems are not only generated in the development of disciplines, but also condensed in applied research and interdisciplinary research. Valuable good problems must be highly original and influential. Secondly, basic research generally has a long cycle, and breakthrough points are often unpredictable. Solving scientific problems requires great efforts, finding good methods, and constantly trying to make mistakes. Sometimes, it also requires research paradigm changes. In this regard, we should work hard from four aspects: first, we should step up the forward-looking layout and organize large teams to carry out systematic research around the fields of information science, material science, synthetic biology and other fields that stimulate major scientific issues; Second, improve the deployment of major scientific and technological projects, strengthen infrastructure construction, and provide a high-level platform for basic research; Third, we should attach importance to the role of the main force of basic research in colleges and universities, and maintain sustained and stable investment in basic disciplines; Fourth, we should attach importance to the training of young talents, effectively solve the problem of evaluation mechanism, and encourage young people to focus on major issues and focus on long-term research in key directions. Tian Gang, an academician of the CAS Member and director of the Beijing International Mathematics Research Center of Peking University, encouraged young people to challenge scientific research problems. Today, the country pays more and more attention to mathematics and other basic disciplines, which is very beneficial to the development of basic research. In my opinion, strengthening basic research ultimately depends on talents. How to cultivate a large number of outstanding talents in the field of basic research? First of all, we should have first-class teachers to find talented young people