Recently, the journal Nature published online the white paper of the International Large Science Program on Human Proteome Navigation (π - HuB), initiated by Chinese scientists and jointly signed by teams of scientists from 18 countries. This marks a further enhancement of China's position, academic influence, and organizational leadership in the global life sciences field, and also demonstrates the important contribution of China's proteomics research in promoting global scientific and technological cooperation, building a community of human health and a community with a shared future for mankind. On December 17th, a symposium on the construction of the "π - HuB Plan" was held in Guangzhou. Academicians and experts such as Zhong Nanshan, Zheng Quanshui, E Weinan, and Song Erwei participated in the symposium through online and offline means. More than 20 years ago, the Human Genome Project successfully created a milestone genome "panorama". It is reported that the "π - HuB" project focuses on revealing a "real-time panoramic map" of the proteome of life activities, aiming to draw a human proteome map of the entire human life cycle through the collaboration of influential teams of scientists worldwide, analyze the principles and evolution of human proteome composition, and explore the dynamic changes of the human body in different physiological and pathological states more deeply, comprehensively, and systematically, comprehensively analyzing the internal mechanisms of human development, aging, and disease occurrence. As of now, the "π - HuB Project" has received support from over 20 countries and regions, as well as 114 teams of scientists, forming a global collaborative network with multiple countries and institutions participating and complementing each other's strengths. According to He Fuchu, an academician of the CAS Member and the chief scientist of the "π - HuB Program", the completion of the Human Genome Program has helped the prosperity and take-off of the global bio economy, but its impact on human life, disease and death has not yet reached the initial expectations. Born in the genome, and destined in the proteome. The dynamic changes of proteins in the human body are the key to determining birth, aging, illness, and death. "Currently, the development of global biotechnology has entered a new stage, and the 'π - HuB Project' will fully combine artificial intelligence and big data analysis to promote the development and prosperity of life sciences and human health," said He Fuchu. It is reported that the plan is expected to last for 30 years, and the "core goals" for the first 10 years include building a human proteome map, developing a large-scale model of "metahumans", and building a computationally driven human state "navigation system". According to relevant experts, the implementation of the "π - HuB Plan" will enhance a deep understanding of human biology, promote the development of disease risk assessment, smart healthcare, etc., create a new paradigm for health management, and greatly promote technological progress in the field of protein science. (New Society)