The recently held Central Economic Work Conference clearly stated that 'we must lead the development of new quality productive forces with technological innovation', releasing a clear signal of using technology to lead industrial innovation and building competitive advantages through industrial upgrading. Currently, the adverse effects of external environmental changes have deepened, and China's economic operation still faces many difficulties and challenges. To cope with shocks and risks, overcome difficulties and challenges, ultimately cannot do without development, and the driving force of development comes from technological innovation. Leading the development of new quality productivity with technological innovation, we have grasped the main theme of global technological innovation. Currently, driven by digital technologies such as artificial intelligence and big models, global technological innovation is bursting with vitality, from ChatGPT to Sora, all demonstrating their driving role in global technology and science. Major developed countries attach great importance to technological innovation, especially the development of artificial intelligence, and vigorously adjust their respective industrial policies to promote technological innovation and industrial development, and respond to technological competition. Technological innovation is also the key to high-quality development, especially in the fields of traditional industry transformation and key components of high-tech. Technological innovation brings about changes in enterprise production models, enhances industry added value, and ultimately achieves high-quality economic development. In addition, technological innovation can also alleviate the anxiety of enterprises towards industrial and supply chain security. Against the backdrop of deepening adverse effects brought about by external environmental changes, various "decoupling and chain breaking" and "small courtyards with high walls" have had an impact on the stable development of the Chinese economy, and various entity lists are troubling the normal operation and production of enterprises. Guided by technological innovation, strengthening the dominant position of enterprises in technological innovation, enhancing the independent innovation of enterprise industrial and supply chains, and promoting high-level technological self-reliance and self-improvement, can we solve the security anxiety of Chinese enterprises towards industrial and supply chains. It can be said that leading the development of new quality productive forces with technological innovation is a key move to solve current development problems and promote high-quality development. In this process, it is also necessary to do a good job in "three overall plans": first, to coordinate the relationship between new and old driving forces. There are no sunset industries, only backward enterprises. Traditional industries, strategic emerging industries, and future industries are all important components of the modern industrial system. They are the main battlefield of technological innovation and the main battlefield of new quality productivity. It is necessary to strengthen overall planning and balance, and form innovative synergy. The second is to coordinate the policy combination of scientific and technological innovation. Technological innovation and the development of new quality productivity involve various aspects such as technological innovation, economic development, industrial policies, and talent cultivation. It is necessary to further strengthen policy coordination, make good use of combination punches, form innovative synergy, release innovative momentum through reform, and further promote an innovative environment and social atmosphere conducive to technological innovation and the development of new quality productivity. The third is to balance the relationship between security and development. In the development of new economy, new technology, and new business models, various new problems will always be encountered, especially those related to security. The resolution of these issues relies on development, and only by achieving tangible development can various security issues be eliminated. We should focus on optimizing safety supervision, improving regulatory systems and mechanisms, encouraging prudence and inclusiveness, and providing more development expectations for technological innovation. (New Press) (Assistant to the President of Cao Zhongxiong Comprehensive Development Research Institute (Shenzhen, China), Director of the Institute of Digital Economy and Global Strategy)