The therapeutic effect of traditional Chinese medicine on acute cerebral hemorrhage is significant

2024-12-03

Recently, the Lancet published a clinical research article of traditional Chinese medicine for the first time in 200 years since its inception - Multicenter randomized, placebo double-blind controlled clinical trial of traditional Chinese patent medicines and simple preparations "Zhongfeng Xingnao Oral Liquid" in the treatment of acute cerebral hemorrhage. The study involved 26 hospitals in 12 provinces of China, and ultimately included a total of 1648 patients with acute cerebral hemorrhage over a period of more than 2 years. The conclusion of the article is that this large randomized placebo-controlled double-blind clinical trial showed that Zhongfeng Xingnao Oral Liquid (composed of red ginseng, Sanqi, Chuanxiong, and rhubarb) did not show efficacy in functional recovery, survival, and health-related quality of life in patients with moderate to severe cerebral hemorrhage. Simply put, the Zhongfeng Xingnao Oral Liquid is ineffective in treating acute cerebral hemorrhage. Furthermore, it is proposed that the research results once again demonstrate the need for rigorous randomized controlled trials to evaluate the effectiveness of existing therapies, including traditional Chinese medicine that is widely used around the world. Through this study, people have learned that Zhongfeng Xingnao Oral Liquid cannot treat acute cerebral hemorrhage. But people may be misled - traditional Chinese medicine is just a placebo and cannot cure diseases. How should we view this matter? Firstly, the research findings are scientific and the conclusions are credible. This study, through rigorous evidence-based medicine design and randomized controlled trials (RCTs), has demonstrated at the highest level of evidence that "Zhongfeng Xingnao Oral Liquid" is ineffective in treating acute cerebral hemorrhage. However, please note that this does not prove that traditional Chinese medicine is ineffective in treating acute cerebral hemorrhage. From the perspective of clinical doctors, traditional Chinese medicine cannot cover the whole world with just one prescription. This study used traditional Chinese medicine as a disease differentiation drug for treating all types of cerebral hemorrhage. In the acute phase of cerebral hemorrhage, the traditional Chinese medicine syndromes are mainly wind syndrome, heat syndrome, and phlegm syndrome. The proportion of hot certificates ranges from 45% to 64.57%. Clinically, patients may experience fever, facial flushing, constipation, high blood pressure, headache, and secondary cerebral edema due to intracranial hematoma. In the early stages of cerebral hemorrhage, inflammatory mediators exacerbate brain damage and edema. Laboratory indicators are often high in white blood cells and high in inflammatory markers such as CRP. The theory of integrated traditional Chinese and Western medicine suggests that heat equals inflammation, and acute cerebral hemorrhage requires "extinguishing the fire". The formula involved in this study consists of four herbs: red ginseng, rhubarb, Sanqi, and Chuanxiong, which were cut from the original 11 herbs. In traditional Chinese medicine theory, ginseng is used to replenish vital energy, restore yang, and rescue reverse energy in patients with coma, hypotension, and shock. However, the number of rescues is also limited, far less effective than Western medicine for boosting blood pressure. Modern pharmacological research shows that ginseng can accelerate bleeding, while red ginseng is hotter and more blood activating, and has a significant impact on coagulation function by affecting platelet function to promote bleeding. Is it necessary to use hot drugs such as red ginseng and Chuanxiong for the supportive treatment of acute cerebral hemorrhage, which includes Western medicine treatments such as dehydration, reducing intracranial pressure, fluid replacement, and improving cerebral perfusion? At present, the formula of these four medicines seems incorrect from a clinical perspective, and now it has been proven by The Lancet with the most scientific methods and the highest level of evidence-based medicine that this formula cannot be used for acute cerebral hemorrhage. The core essence of clinical medicine is to treat diseases and save lives. It requires a correct interpretation of diseases, so that effective solutions can be passed down and save lives. Faced with difficult and severe diseases such as acute cerebral hemorrhage, we have over 30 years of experience in treating acute stroke in the integrated traditional Chinese and Western medicine professional group of the National Center for Neurological Diseases. Our treatment plan is a combination of traditional Chinese and Western medicine, combining internal and external factors. Let's work together to achieve a therapeutic effect of 1+1>2. Based on modern pathological mechanisms, we will prescribe medication and come up with a Chinese solution for cerebral hemorrhage. The treatment principles for acute cerebral hemorrhage are: clearing heat, resolving phlegm, detoxifying, promoting circulation, activating blood circulation, and unblocking collaterals. We simplified acute cerebral hemorrhage into heat syndrome and non heat syndrome, and released the "Expert Consensus on Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Acute Hypertensive Cerebral Hemorrhage". Multiple rigorously designed prospective clinical trials were conducted before and after. The results of published SCI papers and an unpublished real-world cohort study of 1602 cases all indicate that traditional Chinese medicine has significant therapeutic effects on patients with acute cerebral hemorrhage. These are all meant to tell the world how we treat acute cerebral hemorrhage and how effective our treatment is. We have been exploring and improving our approach. So, does traditional Chinese medicine need evidence-based medicine to prove its efficacy? In fact, thousands of years of experience are the best evidence-based evidence. Traditional Chinese medicine and Western medicine have different systems for treating diseases, and their evaluations are naturally different. It is not only randomized controlled trials (RCTs) that are evidence-based medicine and reliable. In recent years, Western medicine has also been reflecting and calling for a return to the original evidence-based medicine, which provides available research evidence that can be combined with actual medical conditions and professional skills, so that every patient can receive the best personalized medical services. This is what we often say: people-oriented, efficacy first. In this sense, traditional Chinese medicine is fundamentally logically consistent, and our ancestors gave us a golden rice bowl. (Xinhua News Agency) (The author is the chief physician of the integrated traditional Chinese and Western medicine group in the neurology department of Xuanwu Hospital, Capital Medical University)

Edit:Chen Jie    Responsible editor:Li Ling

Source:People's Daily

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