Recently, the first national standard in the field of organ chips in China, "General Technical Requirements for Skin Chips" (GB/T 44831-2024), was officially released. The reporter recently learned from Southeast University that the team led by Gu Zhongze, the dean of the Suzhou Medical Device Research Institute, has completed the drafting of the standard. Skin chip is a micro cell and tissue culture device generated using an in vitro microfluidic chip, which can simulate the biochemical and physiological characteristics of the skin and has a barrier structure and function Gu Zhongze introduced that skin chips can achieve high-throughput and automated cultivation and detection, and are expected to become effective tools for toxicology testing, drug screening, and cosmetic evaluation. Skin chips or partial replacement of existing simple two-dimensional cell culture experiments, animal experiments, and even artificial skin experiments have become the most cutting-edge and powerful evaluation criteria and experimental tools for skin related in vitro evaluations. The "General Technical Requirements for Skin Chips" released this time were drafted by the Gu Zhongze team, and 21 units including Southeast University, Boao Biotechnology Group Co., Ltd., Jiangsu Aiweide Biotechnology Co., Ltd., Tsinghua University, Southern Medical University, Nanjing Institute of Food and Drug Administration, and Nanjing Institute of Metrology Supervision and Testing cooperated to complete it. This standard mainly specifies the definitions of relevant terms for skin chips, technical requirements for the appearance, cell source, component performance, biological performance, etc. of skin chips, and is applicable to the design, production, and testing of skin chip products using microfluidic chips as carriers. The release of this standard will effectively promote industry norms and empower high-quality development of the industry. Skin chip is a type of human organ chip. Gu Zhongze introduced that human organ chips are organ micro physiological systems constructed in vitro through the cross integration of cutting-edge technologies such as stem cells, biomaterials, and nanoprocessing. They can simulate the main structural and functional characteristics of different tissues and organs in the human body, as well as the complex inter organ connections, to predict the human body's response to drugs or different external stimuli. At present, the Gu Zhongze team has broken through technical bottlenecks in the field of human organ chips, such as microstructure induced tissue/organ growth, controllable manufacturing of organ chips and biosensors across scales, and multimodal in-situ/online measurement of organ chips, forming a complete technical system for organ chips. The team also successfully constructed China's first organ chip model to enter the space station and conduct scientific experiments, and was the first internationally to propose a drug screening paradigm that integrates organ chips with artificial intelligence. (New Society)