Entering the research institute area of Jilin University of Traditional Chinese Medicine, a microscopic sand table of Changbai Mountain is very eye-catching. Ginseng, Ganoderma lucidum, Platycodon grandiflorus... On this sand table, the location distribution of the main authentic medicinal herbs in Changbai Mountain is clearly marked Dong Fang, a lifelong professor at Jilin Academy of Traditional Chinese Medicine, introduced that Changbai Mountain is known as the "treasure trove of world biological resources" and is also one of the three major gene banks of Chinese medicinal materials. In the 1970s, researchers from the Institute of Materia Medica spent five years conducting a comprehensive survey of the medicinal resources in the Changbai Mountain range, collecting 1533 plant and animal medicinal specimens, and forming a series of achievements such as the Changbai Mountain micro sand table, laying a solid foundation for the comprehensive utilization of Changbai Mountain's medicinal resources. In recent years, Jilin University of Traditional Chinese Medicine has continued the research and exploration spirit of the older generation of scientists, relying on the authentic medicinal resources of Changbai Mountain, and has achieved fruitful results in experimental research and clinical application of innovative Chinese medicine drugs, drug efficacy substance basis research, drug safety evaluation, etc. We will continue to strengthen the innovation of traditional Chinese medicine research technology, use modern scientific and technological means to improve and perfect the research methods and technical means of traditional Chinese medicine, and enhance the accuracy and reliability of traditional Chinese medicine research. At the same time, we will carry forward the advantages of our hospital's close integration of clinical and scientific research, strengthen the deep exploration and mechanism research of authentic medicinal ingredients, and enable authentic medicinal materials in Jilin Province to be more effectively applied in clinical practice and serve people's health, "said Jing Tao, Secretary of the Party Committee and Dean of Jilin Academy of Traditional Chinese Medicine. Using technology to elucidate the principle of traditional Chinese medicine in treating diseases, one formula for soil and water nourishment and one formula for medicinal herbs. Jilin Province, located in the hinterland of Northeast China, has a good ecological environment suitable for the growth of natural green Chinese medicinal materials. There are over 2000 medicinal plants, and the production of more than ten authentic medicinal materials such as ginseng, deer antler, and schisandra ranks among the top in the country. Especially ginseng, which accounts for over 80% of the total national production. In order to gain a deeper understanding of the information on these medicinal resources, the reporter recently visited Jilin University of Traditional Chinese Medicine for research. Changbai Mountain is a 'three-dimensional resource treasure trove', and the medicinal materials here have excellent quality, "said Dong dialect. The more than 900 types of Chinese medicinal materials in Changbai Mountain provide unique medicinal biological resources for the development of the traditional Chinese medicine industry. Good medicinal herbs make good medicine. In recent years, Jilin Province has attached great importance to the development of the traditional Chinese medicine industry, relying on its unique medicinal resources, strengthening technological support, and promoting the deep integration and development of the traditional Chinese medicine industry. In this process, how to use modern scientific technology to elucidate the principles of traditional Chinese medicine in treating diseases has become the main research direction of relevant institutions. When traditional Chinese medicine theories are deduced under the modern natural science research system, they may not be fully reflected in evidence-based research Jing Tao said, "The same medicine may be effective for patient A, but not for patient B. How to explain it scientifically? Then we should speak with indicators and extract the effective ingredients of this medicine for analysis." Taking ginseng research as an example, Huo Feng, Vice President of Jilin Academy of Traditional Chinese Medicine, introduced that the institute has conducted in-depth research on the main components of ginseng (such as ginsenosides and ginseng polysaccharides) and their mechanisms of action, and for the first time proved the regulatory effect of ginseng glycoproteins on longevity factors and anti-aging effects. The traditional Chinese medicine concept of ginseng strengthening the body and resisting aging is consistent with modern research results, providing new evidence for scientifically elucidating the biological efficacy of ginseng. After years of development and research, ginseng is no longer a single medicinal plant. Its active ingredients can be processed and applied to more fields, and ginseng skincare products are a typical representative Chen Yinghong, Chief Pharmacist of Jilin Academy of Traditional Chinese Medicine, said. The team led by Chief Pharmacist Ding Tao has been deeply involved in the research and evaluation of traditional Chinese medicine efficacy for many years. Our research group combines traditional Chinese medicine syndromes with Western medicine disease models, and uses modern omics techniques to deeply and comprehensively explain the principles of traditional Chinese medicine in treating diseases through the combination of disease syndromes and animal models. Taking heart failure as an example, combined with the discussion of traditional Chinese medicine syndromes such as qi deficiency and blood stasis, we simulate the symptoms of heart failure patients, such as shortness of breath, fatigue, palpitations, dark lip color, and spontaneous sweating. The research group establishes specific animal models and uses relevant drugs to verify the effectiveness of the models and further interpret their treatment principles, providing new ideas and methods for the research and clinical application of new Chinese medicine drugs. Exploring the medicinal potential of authentic medicinal herbs using modern technology, discovering new medicinal parts and uses, and expanding the application scenarios of traditional Chinese medicine are also important research directions of Jilin Academy of Traditional Chinese Medicine. For example, Epimedium, which used to be mainly used for tonifying deficiency, later we discovered that this medicinal herb also has a hypoglycemic effect. In order to clarify the medicinal substances involved, we conducted enzymatic and acid hydrolysis, and then converted them into different substances for enzymatic and cellular experiments to determine which substance in which part of it has medicinal effects. We searched for compounds with higher activity and lower toxicity to prepare for the development of new drugs Nan Minlun, a researcher at Jilin Academy of Traditional Chinese Medicine, said that this is also one of the current research hotspots in the field of traditional Chinese medicine. Based on this, in recent years, the institute has undertaken more than 500 national and provincial-level projects, with a total research and development budget of 260 million yuan; Obtained 226 national and provincial-level scientific research awards, 77 national invention patents, 38 national new drug certificates, and 45 clinical approvals. Most of the scientific and technological achievements produced have been transformed into achievements within Jilin Province. One of the most important studies is Ginseng fruit. When it comes to it, many people will think of the ginseng fruit tree in Journey to the West that was knocked down by Sun Wukong, which "blooms once every three thousand years, bears fruit once every three thousand years, and ripens after three thousand years", and others will think of the crisp, juicy, sweet and fragrant melon eggplant. In fact, the "King of Herbs" ginseng fruit is also called Ginseng fruit. Ginseng generally blooms in early summer every year. The flowers are light yellow. Many small flowers gather on the top of the stem and form umbrellas. The flowers fall and bear fruit. The fruit turns from green to red. The bright red ginseng fruit is called "red hammer". Each fruit contains two kidney shaped seeds. "Ginseng fruit is not usually regarded as the traditional medicinal part of Ginseng fruit. The seeds in the ginseng fruit are often used by the people as the source of seeds for planting ginseng, while its pulp is mostly discarded." Mi Hong, the third level chief pharmacist of Jilin College of Traditional Chinese Medicine, introduced that her research group had conducted an in-depth analysis of Ginseng fruit. The research found that Ginseng fruit pulp contains rich ginsenoside Re, Rg1, Rd and other effective ingredients, which has high medicinal value. The research of Ginseng fruit has developed new medicinal parts of ginseng, which makes more effective use of plant resources. On this basis, Mihong led the research team to establish a quality standard evaluation system for Ginseng fruit. "Now many pharmaceutical enterprises, health product manufacturers and food manufacturers in Jilin Province have developed a series of products around Ginseng fruit, including Ginseng fruit tablets, Ginseng fruit juice and other health products. The use of Ginseng fruit instead of traditional ginseng rhizome significantly reduces the production cost. " Mihong said that the market response to these products is good, with annual sales reaching around 100 million yuan. Breaking geographical limitations and creating new formulas, experts say that authentic medicinal herbs are synonymous with high-quality traditional Chinese medicinal herbs in China. They refer to medicinal herbs formed by certain medicinal biological species under the comprehensive effects of specific environmental and climatic factors, with suitable production areas, excellent varieties, high yields, exquisite processing, outstanding therapeutic effects, and regional characteristics. Regionalism "is an important characteristic of authentic medicinal herbs. For example, according to the traditional saying of genuine medicinal materials, safflower is good for Xizang, cordyceps sinensis is good for Qinghai, and achyranthes bidentata has the difference between Sichuan achyranthes bidentata and Huai achyranthes bidentata. Nowadays, relying on modern technology, researchers have proposed a new direction for the development of ancient topics. In theory, I think we should break through geographical limitations and create new solutions through technological means Jing Tao said, "For example, there are 10 kinds of drugs in a certain prescription in Yunnan Province, which specifically treat a certain disease. I choose some drugs from Heilongjiang, Xizang, and Fujian. Together, they can also treat this disease, which can form a new prescription." The reason for creating a new prescription is mainly due to the clinical needs of traditional Chinese medicine. In the past, we couldn't eat watermelon in winter, and northerners couldn't eat seafood. Now, as long as conditions permit, we can put things from all over the world, all year round, on the same table to eat. Is this reasonable and healthy? It's hard to say. But there are some modern diseases that can be said to be 'reversing the Heavenly Stems'. Traditional Chinese medicine doesn't have formulas to deal with it, and innovation is not enough, "said Jing Tao. In theory, the creation of new methods can be achieved thanks to the rapid development of agricultural technology, the continuous advancement of information construction, and the increasingly convenient transportation. By using information technology to achieve information sharing of medicinal herbs, it is possible to create new formulas, "Jing Tao said." For example, if you want to treat heart yang deficiency, ginseng from Northeast China may be good. If you also need diuresis or treatment of heart yin deficiency, ginseng from Yunnan may be good. It is very likely. "Whether it is southern medicine or northern medicine, as long as it can cure diseases, it is a good medicine. Jing Tao said, "In the past, old traditional Chinese medicine practitioners in Hainan couldn't see patients from Northeast China, and it was also difficult for southern doctors to use northern medicinal herbs. Now that conditions are different, it is possible to achieve 'treating southern diseases in the north' and 'using northern medicine in the south' - provided that modern technology proves its effective ingredients. Therefore, the creation of new formulas is at the right time