One kilogram of DNA can hold data from all over the world. Recently, a joint research team led by Zhang Cheng and Qian Long from Peking University proposed a new parallel "printing" DNA storage strategy, successfully printing information on DNA molecules like printing information in batches on white paper. Compared to the current mainstream "word for word" DNA storage based on sequence synthesis, this technology achieves fast and low-cost large-scale molecular data storage, providing a breakthrough new path for the future development of practical DNA storage. The related achievements were published in Nature on the night of the 23rd under the title "Parallel DNA Molecular Data Storage Based on Epimolecular Bit Printing". From oracle bones to bamboo slips, from paper to CDs, from flash memory to cloud storage... With the development of the times, there are profound changes in the way information and data are stored. Nowadays, the world is generating massive amounts of data every day, but where they are stored remains a real challenge. After years of exploration, scientists have discovered that DNA storage technology may be the right option. The reporter learned that mainstream DNA storage often involves chemically synthesizing bases representing information one by one, which is cumbersome and time-consuming, and faces huge challenges in terms of cost and speed. Unlike traditional technological approaches, the core breakthrough of this technology lies in our development of the 'epigenetic molecular bit' DNA storage technology, which utilizes pre fabricated DNA 'white paper' and 'movable type blocks' to' layout 'molecular information mediated by DNA self-assembly, and then' transfer printing 'catalyzed by enzymes, achieving molecular level' movable type printing '. "Zhang Cheng, the corresponding author of the paper, introduced that compared with traditional DNA data storage methods, this parallel writing method for movable type printing only requires limited' movable type blocks' layout to achieve arbitrary information writing, not only avoiding complex and cumbersome DNA sequence encoding processes, but also greatly reducing the complexity of molecular information writing, reducing costs, and improving operational flexibility. Zhang Cheng told reporters that due to the introduction of parallel molecular typesetting and transfer printing mechanisms for the first time, the team successfully wrote high-definition image information of Chinese Han Dynasty tiger patterned tiles and national treasure giant panda Feiyun into DNA molecules in parallel through "epigenetic molecular bits" in experiments, with a data volume of over 275000 bits and a storage scale increased by more than 300 times compared to previous similar works. At the same time, information retrieval can be achieved using a portable nanopore sequencer, which enables high-throughput reading of complex modified bit information on DNA templates and lossless restoration of raw data through parallel parsing. The experimental results validate the feasibility and accuracy of this innovative molecular storage technology, and also demonstrate the stability of 'epigenetic bit' DNA storage. Most notably, the team also demonstrated the potential for distributed storage applications of this technology. The corresponding author of the paper, Qian Long, revealed that in the personal customized DNA storage experiment, the team invited 60 young volunteers with diverse backgrounds. They personally wrote their personal data into DNA in their daily environment and kept it for themselves. The relevant data was not read until they wanted to use it, which effectively protected the privacy and security of personal data. It can be said that this convenient distributed DNA storage method not only greatly reduces the threshold for the use of DNA storage, but also has high privacy, which is expected to realize personal applications of DNA storage. "" Mass printing information on the white paper of DNA represents an important breakthrough and innovation in DNA storage technology, providing a new solution for large-scale data storage. It is expected to break through the cost and speed barriers of DNA storage and lay the foundation for the technological research and development of other related molecular information systems in the future. "Qian Long said," It is foreseeable that in the future, no matter where we are, we will not need to rely on large experimental instruments to achieve simple, accurate, and efficient DNA data storage