People who have had acute ischemic stroke (AIS) or transient ischemic attack (TIA) have a higher risk of experiencing a second stroke or other major cardiovascular adverse events (MACE). A new paper published by a research team in the American Heart Association journal Stroke on the 22nd reveals two proteins that may lead to stroke recurrence. The two proteins identified in this study are CCL27 and TNFRSF14, which are associated with MACE after stroke but not with initial stroke. It is known that these proteins can activate inflammation, which plays a crucial role in the occurrence of stroke and many chronic diseases. The research results indicate that inflammation is a contributing factor to the occurrence of MACE in patients after their first stroke. Although previous studies have revealed a link between inflammation and initial AIS or MACE, new research has found that these pathogenic proteins may also have an impact on subsequent MACE. This may lead to potential new drug targets. The research team conducted a genome-wide association study (GWAS) on specific lineages using genetic information and medical history data from two large biobanks. They examined a total of 93422 stroke patients, of whom 51929 subsequently developed MACE and 45120 subsequently developed AIS. (New Society)