According to the China Rice Research Institute, the team led by Academician Hu Peisong has successfully created a two-line hybrid rice with ultra-low accumulation of cadmium and arsenic in grains, providing a solution for producing rice without exceeding heavy metal standards in areas with combined pollution of cadmium, arsenic, and other heavy metals. The relevant research results were recently published online in the Plant Biotechnology Journal. It is reported that researchers first studied the cadmium reduction ability of key genes related to cadmium regulation under the background of Zhongjiazao 17 and C Liangyou 17 hybrid rice series, and obtained low cadmium variety lines with the best cadmium reduction effect and excellent comprehensive agronomic traits. Meanwhile, plants carrying different cadmium and arsenic regulatory genes were created using the main genes involved in arsenic absorption and transport in rice. Using the above-mentioned plants for grouping, and conducting heavy metal element determination on the grains of subsequent hybrid rice combinations, in the field planting environment, rice carrying cadmium regulatory genes showed a reduction of 64.6% to 85.2% in cadmium content in the grains; Rice carrying arsenic regulated genes showed a decrease in arsenic content in grains ranging from 42.3% to 48.2%; Rice carrying both cadmium and arsenic regulatory genes showed a significant decrease in cadmium and arsenic content in the grains, with cadmium content decreasing by 72.9% to 78.8% and arsenic content decreasing by 42.9% to 53.2%. Finally, based on the determination of rice quality and comprehensive agronomic trait examination, researchers screened hybrid rice lines with synchronous ultra-low accumulation of cadmium and arsenic and excellent comprehensive trait performance, as well as the optimal genotype combination. This study is of great significance for improving the safety and quality of rice and ensuring consumer health. This study was supported by projects such as the National Natural Science Foundation of China, the Zhejiang Provincial Natural Science Foundation, and the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences. (New Society)