The reporter learned from the National Health Commission that three departments, including the National Health Commission and the National Bureau of Disease Control and Prevention, have recently jointly issued a notice on the establishment of a national polio virus storage regulatory agency (hereinafter referred to as the "Notice"), jointly establishing a national polio virus storage regulatory agency, coordinating and promoting the certification of necessary polio virus facilities in China, and maintaining communication and contact with the World Health Organization according to their respective responsibilities. Poliomyelitis is caused by the poliovirus, commonly known as polio. Since 2000, China has been continuously maintaining a polio free state. Why do we still need to establish regulatory agencies for systematic supervision and certification of necessary facilities? The reporter from Science and Technology Daily interviewed relevant experts on this matter. There is still a "last mile" in eradicating polio. Since the World Health Organization launched the Global Action Against Polio in 1988, the number of wild polio virus cases worldwide has decreased by more than 99.99%. "Currently, there are only two countries in the world, Pakistan and Afghanistan, with local outbreaks of wild poliovirus strains." Zuo Shuyan, senior advisor on international organization affairs at the Ministry of International Cooperation of China Biology, told reporters that during the "last mile" process of eradicating polio, China has dispatched multiple experts to relevant countries to support the implementation of enhanced immunization work and supply vaccines to them. "In addition to the transmission of wild strains, there are other transmission risks of polio virus," said Zuo Shuyan. For example, if the live attenuated polio vaccine is used in populations with low vaccination rates or immunodeficiency, there may be a phenomenon of virus virulence regression, leading to paralysis cases. The polio virus has a characteristic that most people infected with the virus do not develop symptoms, but these infected individuals may still cause potential transmission. In addition, to completely eradicate the polio virus, it is necessary to "secure" every possible outlet that may leak the virus. Zuo Shuyan said that with the disappearance of the polio virus in nature, the virus leak may lead to serious consequences of the virus re spreading among people. To avoid the potential risk of leakage from strain preservation institutions, it is necessary to register and seal the strain preservation, in order to truly eliminate the polio virus. Therefore, the 71st World Health Assembly has formed a resolution on the sequestration of poliovirus. "The resolution passed at the World Health Assembly needs to be recognized by all 192 member states, and the content of the resolution needs to be implemented jointly by all member states." Zuo Shuyan said that this is a joint effort made by humanity to eliminate the polio virus. Why do we need to preserve the virus and infectious materials, and which institutions are involved, so as not to let the polio virus take advantage of the situation? "The virus still exists, and in order to avoid its' resurgence ', research institutions, vaccine production enterprises, and inspection and testing institutions need to use relevant strains to complete their infectious disease prevention and control functions. In addition, the strains of pathogens also need to be preserved to prevent future problems." Zuo Shuyan explained, for example, companies need strains to produce vaccines, research institutions, and testing institutions need strains to conduct research and use of relevant standards. ". The Notice mentions that the national polio virus storage regulatory agency is specifically responsible for formulating work rules for regulatory agencies, organizing investigations, updating the list of potential polio virus facilities, and organizing relevant experts to establish a review team to certify polio virus facilities. At present, it seems that