British researchers have released an important finding: the first strictly controlled human exposure clinical trial has shown that inhaling specific types of graphene does not have short-term adverse effects on lung or cardiovascular function. This means that graphene, a nanomaterial, can be safely further developed without posing significant risks to human health. The relevant paper was published in the journal Nature Nanomaterials on the 16th. Graphene was first separated in 2004 and is known as a "magical" material due to its ultra-thin, ultra strong, and ultra flexible properties. It may be applied in fields such as electronic products, mobile phone screens, clothing, paint, and water purification. In addition, scientists are actively exploring the role of graphene in targeted therapy for cancer and other diseases, such as making it into implantable devices and sensors. However, before medical applications, all nanomaterials need to be tested for any potential adverse effects. This human experiment used ultrapure oxygen graphene nanosheets (a material that blends with water). Researchers from Edinburgh University and the University of Manchester recruited 14 volunteers who participated in the study under strictly controlled exposure and clinical monitoring conditions. Volunteers wore masks while cycling in a specially designed mobile laboratory and breathed in ultrapure oxygen graphene for 2 hours. Lung function, blood pressure, coagulation, and inflammation levels in the blood were measured every two hours before and after exposure. A few weeks later, the volunteers returned to the clinic and were repeatedly controlled to be exposed to different qualities of graphene oxide or clean air for comparison. The results indicate that inhaling ultrapure oxygen graphene has no adverse effects on lung function, blood pressure, or most other biological parameters. Researchers have noticed slight signs that inhaling this substance may affect the way blood clots form, but this effect is very small. However, further investigation is needed to determine the potential effects of higher doses and prolonged exposure to graphene. Researchers say that nanomaterials such as graphene have promising prospects, but it is necessary to ensure that they are manufactured in a safe manner in order to be more widely used in daily life. Exploring the safety of this unique material in human volunteers has taken a big step towards understanding how graphene affects the human body. This discovery may open the door to the development of new devices, treatment methods, and monitoring technologies. (Lai Xin She)