The cross integration of immunology and other disciplines is becoming a new trend in the field of immunology. This trend not only expands the research boundaries of immunology, but also brings innovative vitality to the rapid development of this field. The reporter learned from Nankai University that the "Frontiers of Immunology Cross Forum", sponsored by the Chinese Immunological Society, co organized by the Tianjin Immunological Association, and hosted by the Institute of Immunology at Nankai University, was recently held at Nankai University. The forum showcased the significant promoting effect of interdisciplinary cross disciplinary approaches on immunological innovation. As a cutting-edge discipline in the current field of life sciences, every breakthrough in immunology theory and methods will greatly promote the development of medicine and life sciences. Immunological research has revealed the basic laws of life activities, analyzed the pathogenesis of various diseases, promoted the development of related pharmaceutical industries, and ensured population and environmental health. With the continuous deepening of research, the field of immunology is facing more and more challenges, such as the complexity of diseases, personalized treatment needs, and the development of new drugs. In the face of these challenges, the integration of multiple disciplines can stimulate new research ideas and technological innovations in immunology, providing new solutions to these challenges. By introducing research methods and ideas from multiple disciplines such as chemistry, pharmacy, materials science, clinical medicine, neuroscience, and bioinformatics into immunology, we can have a more comprehensive understanding of the working principles of the immune system and the role of immune response in health and disease Color Zhang Song, Deputy Director of the Institute of Immunology at Nankai University, gave an example, saying, "For example, the application of bioinformatics and artificial intelligence not only improves our ability to analyze immune research data, but also provides a unique perspective to interpret complex immune responses, thereby promoting the development of immunotherapy." Academician Cao Xuetao, Director of the Institute of Immunology at Nankai University, emphasized the core issues in the field of immunology in his speech, showcasing his team's achievements in the intersection of immunology, structural biology, and cell biology. He also introduced the hot topic of new developments in immune response and immunotherapy. The team has recently made a series of new advances, including the heteronuclear ribonucleoprotein A2B1 (hnRNPA2B1) which can be used to recognize pathogenic DNA and subsequently initiate interferon IFN- α/β It plays an important role in generating and enhancing the transmission of dependent antiviral signals STING. Similar to hnRNPA2B1, the TLR3 like receptor is also an intracellular pattern recognition receptor that can recognize extracellular RNA and regulate innate immunity through an endosomal biological process dependent manner Cao Xuetao stated that the smooth progress of this work is due to the deep intersection of immunology, structural biology, and cell biology. Wu Yuzhang, academician of the CAE Member and director of the Institute of Military Immunology of the Army Military Medical University, emphasized the importance of the immune system in tumor treatment, as well as the forward-looking role of immune regulation in tumor and innovation of new technological means. At present, the world's most cutting-edge tumor immunotherapy methods, such as immune checkpoint targeted therapy, adoptive T cell transfer therapy, cancer vaccines, and immunotherapy combined with stereotactic radiotherapy (ISABR), all highlight immunology and synthetic biology