On the 14th, Science magazine announced the top ten scientific breakthroughs for 2023, with the development of glucagon like peptide-1 (GLP-1) receptor agonists and the discovery of drugs that can alleviate obesity related health problems as the top breakthroughs of the year. Weight loss and overweight have always been challenging topics in the fields of science and public health. There are many reasons that can lead to obesity, and there is a life-threatening risk. However, in the process of weight loss medication treatment, the stigmatization of overweight has always been an issue that cannot be ignored, as it often leads people to associate overweight with a person's weak willpower rather than biochemical factors. Now, a new drug therapy for weight loss has emerged and shown more exciting results. This year, two landmark clinical trials further showed that the GLP-1 receptor agonist originally developed for the treatment of diabetes produced more significant health benefits than the weight loss effect later found. Currently, researchers are conducting several trials to investigate their effectiveness in treating drug addiction, Alzheimer's disease, and Parkinson's disease. "Although GLP-1 receptor agonists have promising prospects, they pose much more questions than they answer, and this is a true breakthrough," wrote Holden Thorpe, editor in chief of Science magazine, in a related editorial. The review article suggests that the development of GLP-1 drugs will drive discussions on obesity, which will help reduce the stigmatization of overweight. However, the review article also points out people's concerns about the cost, availability, related side effects, and the possibility of indefinite use of these drugs. Doctors are also concerned that people who are not obese or overweight may seek GLP-1 drugs to achieve rapid weight loss. The annual scientific breakthrough list also includes: an antibody therapy that may slow down neurodegenerative changes in the brain of Alzheimer's disease patients; Discovering natural hydrogen sources below the surface; Promote systematic changes in the treatment of early career scientists by global institutions; Confirmed the antiquity of human footprints discovered in an ancient lake in New Mexico, United States; The important carbon pump on Earth is slowing down; Interstellar signals generated by large-scale black hole mergers; The development of artificial intelligence assisted weather forecasting; New malaria vaccines; Deployment of E-level supercomputing. (Lai Xin She)