Science and Technology Daily, Beijing, December 6th (Reporter Zhang Mengran) A biological science paper published in the journal Nature on the 6th proposed for the first time a new method to analyze the aging of human organs, which can better predict disease risk and the impact of aging. This survey analysis of over 5000 people shows that nearly 20% of them exhibit significant accelerated aging of a certain organ, indicating the possibility of organ specific diseases or an increased risk of death. Aging causes the decline of organizational structure and function, leading to a rapid increase in the risk of most chronic diseases. Previous animal studies have shown that aging varies between individuals and between organs within the same individual, but it is still unclear whether this applies to humans and its impact on age-related diseases, as well as how molecular changes occur in human organs with age. In view of this, the research team from Stanford University in the United States evaluated the levels of human plasma proteins from specific organs, measuring the aging differences of different organs in living individuals. Using machine learning models, the team analyzed the aging of 11 major organs (heart, fat, lungs, immune system, kidneys, liver, muscles, pancreas, brain, vascular system, and intestine) in 5676 adults throughout their lifecycle. After evaluating organ age, they found that 20% of people showed accelerated aging of one organ, and 1.7% showed aging of multiple organs. The research team found that accelerated aging of organs increases the risk of death by 20-50%, and specific organ diseases are associated with faster organ aging. Individuals with accelerated aging of the heart have a 250% increased risk of developing heart failure. In addition, accelerated aging of the brain and blood vessels can predict the progression of Alzheimer's disease, just as strong as the predictive power of phosphorylated tau protein (the main diagnostic marker of the disease). Just like cars and houses, the speed of aging in different parts of the human body actually varies. In this study, scientists used blood tests to provide different aging data for 11 key organs, organ systems, or tissues in the human body. This allows people to detect organs that are accelerating aging in their bodies by monitoring the condition of various organs in seemingly healthy individuals. If this research finding can be replicated in a larger population, it can be intervened and treated in advance before people fall ill. At the same time, it is also expected to bring new drug targets to humanity. (Lai Xin She)