After 5 years, over 350000 hours of genome sequencing, and an investment of over 200 million pounds, the UK Biobank released the world's largest whole genome sequencing data to date on the 30th, completing the most eye-catching project of its kind in history. Rory Collins, Chief Researcher at Biobank UK, stated that for scientists engaged in health research, this is a true treasure trove that can bring change to global diagnosis, treatment, and healing. As an important milestone in medical research, the UK Biobank has released new genome-wide sequencing data from 500000 participants. This will drive the emergence of new diagnostic, therapeutic, and healing methods, and more uniquely, by stripping names, addresses, dates of birth, and names of general practitioners, this protected database is available for authorized researchers worldwide. This achievement provides the most detailed human health status to date, contributing to the "ultimate toolbox" for researchers, making previously impossible connections and discoveries about disease development possible. Collins said that the absolute amount of genetic data is astonishing, and these data are also very inspiring because they were obtained after tracking the health status of volunteers for about 15 years. The researchers first achieved a series of significant leaps using the vast biomedical database of the UK Biobank, and based on this, they obtained sequencing data for this study. These leaps include: finding genes related to the prevention of obesity and type II diabetes, which may lead to the development of new drugs; Identifying individuals with high genetic risk of heart disease, breast cancer, prostate cancer and other diseases may help screening; The relationship between exercise and Parkinson's disease can be predicted 7 years before diagnosis based on smartwatch data, which may lead to early intervention. Researchers say that the new findings will greatly enhance the potential of existing data. What is the relationship between your genes, lifestyle, and health status? A large-scale gene and environmental factor information database can tell us the answer. Biobank UK was founded 20 years ago, and so far, more than 30000 researchers from over 90 countries have registered to use the bank and published over 9000 peer-reviewed papers. This time, this database recruited 500000 selfless volunteers to create the world's most comprehensive source of health data, which not only includes precious genetic information and blood samples, but also covers people's lives, behaviors, environmental factors, and all medical records. The result will undoubtedly greatly improve human understanding of pathogenic genes. (Zhang Mengran) (Lai Xinshe)