At present, various respiratory pathogens such as Mycoplasma pneumoniae, influenza, and Streptococcus pneumoniae are in the epidemic stage. The majority of patients are children, and many adults have been recruited. Some patients have also experienced co infection with multiple pathogens such as Mycoplasma pneumoniae and influenza. Who are more susceptible to co infection and will it worsen the condition? Respiratory physicians provide detailed answers for everyone. At present, the most prevalent pathogens are Mycoplasma, influenza virus, and Streptococcus pneumoniae. These respiratory tract infections generally present with symptoms such as coughing, coughing, runny nose, fever, and overall fatigue. However, each disease has typical characteristics: Mycoplasma infection generally occurs slowly, with patients mainly experiencing stubborn dry cough, and some patients may also experience symptoms such as skin rash; Influenza is often an acute disease, with patients mainly experiencing high fever symptoms, which can cause a fever of over 38.5 ℃; The infection of Streptococcus pneumoniae is generally acute, and patients often experience chills and chills after catching a cold, with a high fever ranging from 38 ℃ to 39 ℃, accompanied by chest pain, and sputum often showing a rust like appearance. Generally speaking, if persistent fever persists for up to 72 hours, and persistent dry cough affects normal life, chest pain, wheezing, and other symptoms occur, it is necessary to seek medical attention in a timely manner. At this point, the pathogen may not only stay in the upper respiratory tract, but may have already invaded the lower respiratory tract, and there may even be a possibility of pneumonia. Generally speaking, there are few completely single infections among the four groups of people who are aggravated by co infection. Viruses can be mixed with bacteria, and mycoplasma can also be infected with bacteria. At present, there are more cases of Mycoplasma combined with bacterial infections, especially among hospitalized pneumonia patients. Superimposed infection causes certain damage to immune function, and has a greater impact on the lungs, deepening the degree of infection, leading to worsening symptoms, large dosage of medication, long course of disease, and difficult treatment. There are four types of people who are more prone to co infection, one is school-age children and middle-aged and elderly people over 65 years old; One type is living in a humid and non ventilated environment; People with unhealthy lifestyle habits such as smoking, excessive drinking, and improper diet; Patients with chronic respiratory diseases, such as chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, etc., are more likely to develop concurrent infections without proper protection. After being recruited, there are antibodies, but don't take it lightly. Infection with Mycoplasma usually produces antibodies within 5 to 7 days, and the antibodies can last for 2 to 6 months. However, with antibodies, there is also a possibility of re infection. Mycoplasma has diverse forms and there is no targeted vaccine. The production time of influenza antibodies varies from person to person, and can last for 3-12 months. Antibodies will appear after 1-2 weeks of infection with Streptococcus pneumoniae, and antibody concentrations begin to decrease after 6-8 months. Some patients may experience a situation where a disease happens and is transmitted within a few days. This is mainly because, even if the body has recovered, the immune function will be damaged to some extent due to this infection, and it will worsen when encountering different bacterial infections. At present, there are preventive vaccines for influenza and Streptococcus pneumoniae. But everyone should be aware that either they have been vaccinated or they have entered the safe. They have been infected with the epidemic