On the 26th, the reporter learned from Xiamen University that the team of Academician Huang Wei and Professor Li Lin from the Institute of Flexible Electronics (Future Technology) of the university, in collaboration with Associate Professor Peng Bo from Northwestern Polytechnical University, has designed a two-photon fluorescence probe for rapid detection of human brain glioma markers. This achievement is expected to be applied to early diagnosis and intraoperative navigation of tumors. The relevant results were recently published in the international journal "German Applied Chemistry". Glioma is the most common primary central nervous system tumor. Previous studies have shown that the abnormal expression of monoamine oxidase A (MAO-A) is closely related to the occurrence and development of glioma, and is an effective target for the diagnosis and treatment of glioma. This study focuses on monoamine oxidase A, selects two-photon fluorophores that are suitable for its cavity size, and designs and synthesizes a two-photon fluorescence probe with high affinity and selectivity. Used for rapid detection of MAO-A content in human glioma cells and tissues. Research has shown that this new two-photon fluorescence probe can detect biomarkers within 20 seconds, making it the fastest known fluorescence probe for detecting monoamine oxidase A. Moreover, this probe can accurately detect and distinguish the content of biomarkers in different cell lines. The research results indicate that this probe has great potential for clinical rapid diagnosis of glioma and navigation during fluorescence surgery. Industry insiders believe that due to the invasive growth characteristics of gliomas, there has been no clear boundary between them and brain tissue, making it difficult to completely remove them through surgery. Based on real-time imaging technology using fluorescent probes, fluorescent molecular probes can "light up" cancer cells in real-time during surgery, providing a "map" guide for surgical procedures, breaking through the accuracy limit of traditional surgical treatments, and demonstrating great clinical value. (New News Agency)