With the optimization of epidemic prevention and control measures, the flow of personnel has increased significantly. While enjoying the magnificent scenery of the motherland, the risk of COVID-19 infection cannot be ignored. So, infected with COVID-19, you need to take Antiviral drug? How should I take anti COVID-19 drugs? In response to these questions, the reporter interviewed Professor Yao Wei, director of the Department of Respiratory Medicine of the Third Affiliated Hospital of Chongqing Medical University. The susceptible population needs to pay attention to protection. Negative antigen does not mean that we can relax our vigilance. Ask: What are the susceptible population of COVID-19? How to prevent COVID-19 infection at present? Professor Yao Wei: The susceptible population of COVID-19 includes people who have not been infected in the past, people who have not been vaccinated, etc. In addition, people who have been infected with COVID-19 for the first time for more than 6 months are also at risk of re infection due to the reduction of antibodies in their bodies. It is recommended to vaccinate or vaccinate again after 3 months of infection to stimulate the antibody level in the body to rise again and reduce the risk of infection. At the same time, it is necessary to wash hands frequently, pay attention to rest, and engage in appropriate outdoor activities; Family and friends gathering during holidays may rest late, but staying up too late can lower immunity, and attention should also be paid. Q: There have been symptoms of COVID-19 infection such as dry throat and fever, but the antigen test shows that it is still negative. How many days after the general infection, can COVID-19 infection be detected by antigen detection? Will the above situation delay the timing of medication use? Professor Yao Wei: Nowadays, many people do their own antigen testing, but there may be some lag in antigen testing. When I first became infected, I tested positive for the antigen three days after experiencing symptoms, but on the second infection, I tested positive on the first day of the symptoms. Therefore, there is a difference in the timing of the occurrence of positive antigen testing. For high-risk people, that is, vulnerable people, if there is a history of contact with COVID-19 or there are corresponding symptoms, even if the antigen is negative, Nucleic acid test should be carried out as soon as possible. If the nucleic acid test is also negative, but there are pneumonia or other serious symptoms, it is crucial to initiate antiviral treatment in the early stages of infection. What should we do when we have symptoms? Can Antipyretic replace COVID-19 Antiviral drug? Ask: What should we do when we have COVID-19 symptoms? Professor Yao Wei: The current Omicron strain is not highly viral, and many patients have mild symptoms even if infected. The first thing to do is to relax and actively respond. Once diagnosed and COVID-19 symptoms appear, it is best to take anti COVID-19 drugs within "golden 72 hours" to minimize the harm to the body and reduce the ability of social transmission. Q: Can the Antipyretic with high fever during the last wave of the epidemic replace COVID-19 Antiviral drug? Professor Yao Wei: The mechanism of Antiviral drug is to inhibit the replication of the virus, so as to shorten the course of disease and improve the quality of life. Because most of the symptoms of COVID-19 patients are mild, they may have fever, runny nose, sneezing, coughing and other symptoms, but there is no lung infection, so Antipyretic drugs can be used to alleviate symptoms in the early stage. But for vulnerable people, COVID-19 infection is easy to cause pneumonia, leading to severe cases, so such patients need to use Antiviral drug. In addition, patients with severe symptoms and more symptoms of COVID-19 who need to relieve symptoms as soon as possible are also recommended to take COVID-19 Antiviral drug. Between the two