On June 13, the reporter of Science and Technology Daily learned that Zheng Hairong, a researcher team of the Chinese Academy of Sciences Shenzhen Institute of Advanced Technology (hereinafter referred to as the Shenzhen Institute of Advanced Technology), had developed a phased array holographic acoustic tweezers manipulation technology, which successfully achieved non-invasive precise manipulation and efficient enrichment of bacteria containing air bags in organisms and blood flow, and achieved the application of Targeted therapy for tumors in animal models. The relevant research paper was published in the international journal Nature Communications. Compared to other methods, acoustic tweezers designed based on high-frequency acoustic gradient sound fields have unique advantages in organisms such as high force, strong penetration, high control flux, and no need for labeling. "Corresponding author Zheng Hairong stated that if acoustic methods can be used, without the need for intervention, drugs and therapeutic cells can be accurately transported to the lesion site of the organism, solving a major challenge in clinical treatment. In response, the team proposed and constructed a programmable phased array holographic acoustic tweezers theory, technology, and instrument system, laying the foundation for precise acoustic manipulation in complex environments such as organisms. The phased array holographic acoustic tweezers instrument system is based on high-density surface array transducers to generate tunable three-dimensional volume sound waves. By precisely regulating the spatiotemporal and spatial characteristics of the spatial sound field in complex environments such as living blood vessels, it can successfully manipulate bacterial clusters containing airbags to accurately move to the target area and perform therapeutic functions. It is expected to provide an ideal means for targeted drug delivery and cell therapy of tumors, "Zheng Hairong said. In this system, the team pioneered the use of time inversion to correct the distortion caused by sound waves passing through non-uniform media, combining ultrasound imaging with three-dimensional acoustic manipulation, achieving the self navigation of three-dimensional acoustic tweezers in non-transparent non-uniform media, and taking the lead in breaking through the bottleneck problem of acoustic manipulation in complex environments; At the same time, it has promoted the miniaturization of two-dimensional high-density ultrasound transducer arrays, integrated microscopic imaging, and preliminarily achieved in vitro three-dimensional acoustic manipulation verification of cells, microorganisms, etc. The strong gradient sound field formed by a two-dimensional high-density ultrasound transducer array is like an invisible 'tweezer', controlling bacteria to accurately follow a predetermined route to reach the lesion site, "said team member researcher Ma Teng. This study demonstrates that phased array holographic acoustic tweezers can serve as a new tool for non-contact and precise manipulation of cells in vivo, "Zheng Hairong said. (Outlook New Era Network)