On May 21st, the 2023 Greater Bay Area Science Forum held its opening ceremony and main forum. Ding Zhaozhong, winner of the Nobel Prize in Physics and foreign academician of the Chinese Academy of Sciences, Michael Levitt, winner of the Nobel Prize in Chemistry and professor of Stanford University in the United States, Teng Jinguang, president of the Hong Kong Polytechnic University and academician of the CAS Member, Ye Yuru, president of the Hong Kong University of Science and Technology and academician of the CAS Member, Gao Wen, director of Pengcheng Laboratory and academician of the CAE Member, made keynote reports successively. The innovation and development of the Guangdong Hong Kong Macao Greater Bay Area and international cooperation in scientific and technological innovation have become topics of common concern for scientists. ChatGPT, artificial intelligence, clean energy and carbon neutrality are high-frequency words on the main forum. Exploring the establishment of the Greater Bay Area Research Funding Fund as the highest level scientific event in the Guangdong Hong Kong Macao Greater Bay Area, the Greater Bay Area Science Forum focuses on the construction of an international science and technology innovation center, showcasing the important achievements of scientific and technological innovation in the Greater Bay Area in all aspects. The supercomputer Pengcheng Cloud Brain II developed by Pengcheng Laboratory in Shenzhen is a representative achievement. Gao Wen introduced that Pengcheng Cloud Brain II ranks first in the world in terms of computing power on authoritative rankings, which not only responds to national strategies but also serves local needs, supports the major application needs of artificial intelligence in Shenzhen, and enhances the fundamental position and innovation of artificial intelligence research in the Greater Bay Area. At present, only 1/4 of the machine hours of Pengcheng Cloud Brain II are used for laboratory research, while the rest are open to partners such as universities, research institutions, and enterprises. We have already conducted multiple collaborations with companies such as Huawei, and will continue to promote open source openness, serve scientific research and industry, and build an artificial intelligence ecosystem in the future, "said Gao Wen. Teng Jinguang and Ye Yuru are both presidents of Hong Kong universities. In their view, from talent cultivation to the field of people's livelihood, Guangdong Hong Kong Macao technology cooperation and collaborative innovation have achieved many achievements, and there is greater room for imagination in the future. The Hong Kong Polytechnic University attaches great importance to interdisciplinary talent cultivation and scientific research, and emphasizes the use of innovative technologies to benefit society. "Teng Jinguang said that the school has close cooperation with mainland cities in the Greater Bay Area in terms of knowledge transfer and industrialization of achievements. For example, among the four "unicorn" enterprises founded by students from the school, three have settled in Shenzhen. Teng Jinguang revealed that in the future, the Hong Kong Polytechnic University will establish several technology innovation research institutes across the country, "with the director of the Polytechnic University to connect with industry demand. For further enhancing scientific and technological cooperation in the Greater Bay Area, he suggested establishing a Greater Bay Area Research Funding Fund, jointly funded and used by 11 cities, to support the construction of research and development platforms and projects in the Greater Bay Area. At the same time, it is possible to promote the establishment of a number of laboratories in the Greater Bay Area, jointly build large scientific facilities, and explore the establishment of short-term (1 semester to 1 year) teacher exchange programs, as well as increase opportunities for student exchange and exchange. Ye Yuru also believes that different cities in the Greater Bay Area can complement each other's advantages and achieve coordinated development. They can cooperate at different stages of the innovation chain, integrate national and global science and technology innovation resources, and build a world-class science and technology innovation ecosystem. As a neurobiologist, she takes technological innovation to address the challenges of aging as an example to say that the Greater Bay Area has many well-known universities, top tier medical institutions, numerous pharmaceutical enterprises, and biotechnology companies, which not only have research resources but also an industrial development foundation. Therefore, it is necessary to strengthen cross disciplinary and cross regional efforts