Currently, multiple factors such as geopolitical and epidemic situations are profoundly affecting the stability of the global industrial chain supply chain. Under the new situation, what new adjustments have taken place in the global industrial chain supply chain structure? What impact will the transfer of some industrial chains and supply chains have on manufacturing in China? How can enterprises make a reasonable layout and find the "optimal solution" of the industrial chain supply chain? On the afternoon of March 28th, at the "New Pattern of Industrial Chain Supply Chain" sub forum of the 2023 annual meeting of the Boao Forum for Asia, participants held a heated discussion to seek "certainty" among "uncertainties". "China remains the world's leading manufacturing hub," said Feng Bo, deputy general manager of COSCO Shipping Group, who described the new changes taking place in the global industrial chain supply chain with three "series". "In the past, we were more cost oriented, but now we are more concerned about safety." Liang Weite, the consultative committee of the Boao Forum for Asia, the former director of the Department of Economy and Finance of the Macao Special Administrative Region Government, and the chairman of the Macao Committee for the Construction of the Guangdong-Hong Kong-Macao Greater Bay Area of the Boao Forum for Asia, believes that "in order to cope with the new situation, enterprises have transformed the 'global supply chain' into the 'local supply chain'. Of course, this is also a challenge for enterprises in recent years.", The relocation of some manufacturing enterprises and some multinational enterprises in China has caused some worrying voices. Yao Yang, president of the National Development Research Institute at Peking University, expressed confidence in his speech: "If the proportion of China's economy and the volume of trade are considered, the part of relocation is relatively small. Moving some labor intensive enterprises out of China is not necessarily a bad thing, but may instead be a good thing. This means that China's industry has been upgraded, and it also means that neighboring countries will be more closely integrated with China's manufacturing industry." Yao Yang pointed out, To some extent, this is the result of the active upgrading and upgrading of China's internal industrial chain and the accelerated optimization and restructuring of external global industrial chains. "China remains the world's leading manufacturing hub.". Fabrizzo Ferry, head of Asia Pacific and CEO of China for Fincantini Group, also believes that although some companies are trying to localize their supply chains in Southeast Asian countries such as Vietnam, "But I believe that China will still be a production center." "Our main research and development center is in China, and production facilities may be located overseas to meet customer needs, but many equipment, technology, and materials are from China, which is the key." Zhu Shihui, chairman of Pioneer Technology Group Co., Ltd., said that despite geopolitical conflicts, the pace of innovation and cooperation cannot be stopped. Closer cooperation will eventually bring light to the light. In the context of accelerated evolution of unprecedented changes in a century, empowering the industrial chain supply chain and strengthening its resilience and impact resistance are important ways to base on current economic development needs and improve industrial layout and transformation. "Whether it's climate change, epidemic risk, or geopolitical impact, we need to strengthen the resilience of supply chains and industrial chains to meet challenges," said Bei Zhemin, managing partner of Aowei Consulting. "More cooperation and more harmonious industrial chains are the safest industrial chains, and the world can benefit from them." Liang Weite said, "In order to have a safe production