Several years ago, Mr. Cheng suffered from severe sequelae due to a sudden herpes zoster in the occipital region. Since then, various forms of pain such as lightning, knife cutting, pulling, ant bite and so on have often alternated, with more than 40 attacks per minute at the peak, which made him miserable. In recent years, Mr. Cheng has been seeking medical treatment in many domestic hospitals, but he has not found a way to relieve the pain. Common painkillers have failed for him, and he even used oxycodone, a powerful opioid painkiller, to treat advanced cancer pain. The pain gradually worsened, and the dosage of the drug increased. In the past year, he needed to take more than 20 oxycodone tablets every day. People are also increasingly anxious, restless and unable to sleep. The above examples belong to refractory chronic pain complicated with psychological diseases. Chronic pain is known as "silent epidemic", most of which is caused by tissue injury, chronic disease, psychological factors and other reasons. It is manifested as pain caused by an acute disease or an injury, which exceeds the time required for conventional cure; Or the pain relapses or relapses after several months or years after relief, usually presenting as persistent or intermittent pain for more than 3 months. According to epidemiological survey statistics, about 20% of the world's population suffers from chronic pain, which has become a "global public health priority". The incidence rate of chronic pain is about 41.3% - 52.99% in China. More and more studies show that continuous pain stimulation will cause poor sleep, anxiety, depression, catastrophic cognition and other negative emotions. Negative emotions may be accompanied by other emotional disorders, such as alexithymia, cognitive impairment and even extreme behavior. Therefore, while treating physical pain, the accompanying psychological problems also need to be solved urgently. Treatment of chronic pain cannot be separated from multidisciplinary cooperation. What is the difficulty of chronic pain treatment? The main points are as follows: First, we should avoid the dependence and abuse of opiates; The second is to carry out multimodal pain relief; Third, we should actively prevent and treat psychological diseases caused by chronic pain and promote physical and mental recovery. First, avoid the dependence and abuse of opiates. A large number of survey data show that opioids are still the main drugs for the treatment of chronic pain. The long-term and massive use of opiates has brought about problems that cannot be ignored - drug dependence and abuse. Mr. Cheng needs to take more than 20 oxycodone tablets every day, which has obviously led to dependence on opiates. To reduce the use of opioid drugs, we must control stubborn chronic pain. This also refers to the second point, which is often solved by multimodal analgesia and nerve intervention surgery. Use a variety of drugs with different targets, use a variety of pain control methods, and carry out joint treatment from different angles to effectively control pain and promote rehabilitation. Third, we should actively prevent and treat psychological diseases caused by chronic pain and promote physical and mental recovery. Chronic pain is a disease that is related to actual or potential tissue damage, including the painful experience of feeling, emotion, cognition and social components. Long-term pain and suffering can easily induce anxiety, depression, post-traumatic stress disorder and other psychosocial diseases. Due to its complexity, chronic pain needs to be integrated with biological, psychological and social disciplines