At present, 3D printing customized prosthesis has been widely used in orthopedic clinic, such as 3D printing artificial acetabular prosthesis, scapular prosthesis, pelvic prosthesis, thoracolumbar artificial vertebral body and personalized prosthesis. 3D printing of various shapes of internal plants also helps doctors to solve the treatment problems of difficult and serious diseases such as spinal tumors and severe trauma. "No problem! The previous symptoms are gone..." said a patient in the orthopedic clinic of Peking University Third Hospital recently. Previously, the patient had undergone a vertebral body replacement operation and was implanted with a pure domestic "self-stable" 3D printing titanium alloy microporous structure artificial vertebral body. It is understood that the basic material of the artificial vertebral body is titanium alloy powder, and the 3D printing equipment for producing the vertebral body is also independently developed by China. The implantation of this "self stable" 3D printing titanium alloy microporous structure artificial vertebral body marks that in the orthopedic application field of 3D printing technology, China not only has the ability to independently design and develop relevant innovative products, but also has the ability to produce with domestic equipment and materials, realizing the whole process innovation from original design to product development and manufacturing. Open up a 3D printing bone localization road for vertebral body replacement to be applied to cervical spondylosis, cervical cancer and other patients who need vertebral body resection for treatment. At present, the repair technology of cervical vertebra resection at home and abroad usually adopts the method of titanium mesh plus titanium plate and screw, that is, after the vertebral body is excised, a cylindrical titanium mesh structure is placed in the bone defect area after the vertebral body is excised, and then a titanium plate is placed in front of the titanium mesh, and the upper and lower ends of the titanium plate are fixed on the adjacent vertebral body with screws. Because the device needs to be combined, the fixed strength is weakened. At the same time, the titanium plate for fixation is covered at the front and rear ends of the surgical vertebral body, and the esophagus is in front of the cervical vertebra. The protruding part of the titanium plate is easy to squeeze the esophagus. "The 'self stable' 3D printing titanium alloy microporous structure artificial vertebral body has improved this problem, removing the titanium plate that causes squeezing feeling to the patient, directly combining the screw and vertebral body, and the implant is flush with the surface of the cervical vertebra, realizing the 'zero notch'." As the surgeon of the above patients who implanted the 'self stable' 3D printing titanium alloy microporous structure artificial vertebral body, the director of the Institute of Spinal Surgery, Peking University Third Hospital, professor of orthopedics Liu Zhongjun, the chief physician and the expert group leader of the centralized unit of medical additive manufacturing technology and medical device standardization technology, pointed to the artificial vertebral body model and said that the previous research confirmed that the biomechanical properties of the "self stable" 3D printing titanium alloy microporous structure artificial vertebral body were better than the titanium filler used in the past, and made the operation more simple. He introduced that this "self stable" 3D printing titanium alloy microporous structure artificial vertebral body has been on the market for more than one year in China, and the feedback from medical units is very good, which will be gradually introduced to the international market in the future. With more than 90% of high-end medical devices relying on imports, the localization of 3D printing artificial vertebral body is not easy. As the leader of the national key research and development plan project "Key technology and clinical application of orthopedic personalized implant additive manufacturing", Liu Zhongjun said that this "self stable" 3D printing titanium alloy microporous structure artificial vertebral body was "a little bit groped out". At first, Liu Zhongjun wanted to use 3D printing to make an artificial pivot