"There is no ancient medical book that can tell modern Chinese medicine how to regulate the changes in the microscopic indicators of patients. For thousands of years, the diagnosis and treatment system of traditional Chinese medicine has been a" black box ". People only pay attention to the changes in the state of patients before and after entering the" box ", but do not pay much attention to the specific reactions in the" box "." At the 738th Xiangshan Scientific Conference held on February 17-18, Tong Xiaolin, an academician of the CAS Member, pointed out that the status quo of traditional Chinese medicine (TCM), which is stronger than "state" and less than "target", needs to be changed urgently. Tong Xiaolin said that traditional Chinese medicine pays attention to "regulating the state", that is, by restoring the internal stability of the body, improving symptoms and signs, to achieve the purpose of treating diseases. However, with the gradual micromation of modern medicine's understanding of diseases, the medical community no longer simply takes the improvement of symptoms and signs as the standard of curative effect. In the early stage of the disease, many patients only showed abnormalities in physical and chemical indicators, but did not have corresponding symptoms and signs, which made traditional Chinese medicine often fall into a situation where there was no evidence to distinguish and no evidence to participate. There are "three strong and three weak" in the traditional Chinese medicine diagnosis and treatment system. Tong Xiaolin believes that Chinese medicine pays attention to the holistic view of the relationship between man and nature, and is good at "adjusting the state". This advantage determines that it often has the advantage of overall reversal and preemptive action in the treatment of diseases of complex etiology, diseases of unknown etiology, and emerging infectious diseases. For example, the use of traditional Chinese medicine in the treatment of COVID-19 infection is a good proof. But the traditional Chinese medicine diagnosis and treatment system also has shortcomings. First, "carving" is strong and "axis" is weak. Traditional Chinese medicine's "tone" focuses more on the symptoms of the disease, that is, the "four diagnostic" performance at the time of treatment, and lacks the grasp of the whole process of the disease. This is because, limited by historical conditions, ancient Chinese medicine mostly practiced medicine for individuals, and thus lacked systematic observation of the disease's full cycle time axis. Secondly, the "state" is strong and the "target" is weak. "State" refers to the concept of "regulating state" in TCM, and "target" is divided into "disease target", "disease target" and "target target". "Disease target" refers to the treatment directly aimed at the disease itself, "As long as the 'disease target' of the disease is really found, the application of traditional Chinese medicine does not need to be treated by differentiation of symptoms and signs. For example, the treatment of malaria with artemisinin and the treatment of leukemia with arsenic trioxide are all aimed at the 'disease target'. The 'disease target' is the root of the disease, and finding the root can fundamentally solve the disease. But whether it is traditional Chinese medicine or western medicine, finding the 'disease target' of the disease is currently a difficult problem." Tong Xiaolin said. "Symptom target" refers to the treatment of symptoms or signs, traditional Chinese medicine literature, and the experience of modern famous and old Chinese medicine, all of which are worth learning; "Target" refers to the treatment of physical and chemical indicators of modern medicine, which is the short board of modern Chinese medicine. For example, what medicine can reduce transaminase, creatinine, blood pressure, glucose and uric acid, etc., the ancients have no research conditions and ancient medical books have no corresponding records. Therefore, "target" is a problem that contemporary Chinese medicine must face directly. Thirdly, "individual" is strong and "group" is weak. Traditional Chinese medicine pays attention to the treatment based on syndrome differentiation and individualized treatment for one person, lacks the research on group treatment measures, and obviously lacks the grasp of the common laws of modern diseases, especially chronic diseases. In modern times, the division of special diseases and departments has enabled traditional Chinese medicine to study group treatment. Reconstruction of diagnosis and treatment system is the integration of traditional Chinese and western medicine