Life is like a book full of mysteries, and revealing its new mysteries is the goal of life science research, which can promote the development of new technologies, new breakthroughs in medicine and the development of bioeconomy. On the 19th, the consortium of the Life Sciences Society of the Chinese Association for Science and Technology announced the top ten advances in China's life sciences in 2022. Ten scientific research achievements with outstanding originality and social significance were selected, which focused on how COVID-19 Omikron strain achieved immune escape in human body; Global warming, how can rice resist high temperature and not reduce yield; The new progress in the treatment of cardiovascular, cerebrovascular, diabetes and other diseases and other issues facing people's life and health and the world's hot scientific research will further promote the decoding of the "Book of Life". To solve the hot problems such as COVID-19 immune escape, rice resistance to high temperature, and cell recognition, COVID-19 Omicron strain continues to mutate, causing multiple rounds of epidemic in the world, which is a hot issue that everyone is concerned about at present. At present, it is very important for the research and development of broad-spectrum COVID-19 vaccine and antibody drugs to analyze the humoral immune escape mechanism of COVID-19 mutant. Among the ten major developments announced this time, the research of Xie Xiaoliang and Cao Yunlong from Peking University, together with the research of Wang Xiangxi from the Institute of Biophysics of the Chinese Academy of Sciences and Wang Youchun from the Chinese Academy of Food and Drug Control, has improved the scientific understanding of the prevention and control of the world's COVID-19. They first reported the humoral immune escape characteristics and molecular mechanism of COVID-19 Omicron and its subtype variants. The structural and infectious characteristics of several mutants were analyzed for the first time, and the full epitope distribution and escape map of the neutralizing antibody of COVID-19 were characterized in detail. Food security is fundamental to our country. Rice is one of the main crops in our country. The research on rice has always been concerned. With the global warming, extreme high temperature weather will cause a large reduction in rice production and aggravate the food security problem. The Lin Hongxuan team of the Center for Molecular Plant Science Excellence and Innovation of the Chinese Academy of Sciences and the Lin Youshun team of Shanghai Jiaotong University have cooperated to reveal the new mechanism of high temperature resistance of rice, and have also dug out the high temperature resistance genes of rice, providing valuable gene resources for crop breeding of high temperature resistance, which helps to solve the current urgent problem of cultivating high temperature resistant crop varieties. How can our scientists' research on small cells attract more than 190 scientific research teams from 25 countries to participate? That's right. This is the research from Wang Jian and Xu Xun of the Institute of Life Sciences of the University of China. Based on the independent DNA nanosphere sequencing technology, they developed high-precision large-field space transcriptome technology, which promoted the resolution of understanding life to the subcellular level of 500nm. Compared with similar technologies in the past, the resolution increased by 200 times, and the field size increased by 483 times. Together with several domestic scientific research teams, they also drew the most accurate and comprehensive spatiotemporal gene expression data set of important model organisms such as mice, fruit flies, zebrafish, Arabidopsis and salamanders for the first time in the world, and discovered the whole new cell types that play a key role in the process, which caused a warm response in the world. Bringing good news to patients with cardiovascular and cerebrovascular diseases and diabetes Research and treatment of diseases have always been the focus of life science research. Among the ten major advances announced this time, many studies focused on cardiovascular, cerebrovascular and glucose