Global scientific and technological innovation is entering an unprecedented intensive and active period. The fourth industrial revolution is restructuring the global innovation landscape and reshaping the global industrial structure. Guangzhou has established a relatively complete manufacturing system, and Guangzhou manufacturing enjoys a high reputation at home and abroad. However, Guangzhou is also faced with challenges in implementing the strategy of building a city with manufacturing industry. First, the innovation ability of enterprises needs to be improved. The number of enterprises with state-level R&D platforms in Guangzhou has yet to be improved, and it is urgent to strengthen their efforts in winning state-level science and technology awards and China Quality Awards. Second, the number of leading enterprises with international influence needs to be "expanded", and the number of enterprises entering the list of the world's 500 compulsory manufacturing enterprises needs to increase. Third, emerging industries with distinctive characteristics of the times, such as chip manufacturing, big data and artificial intelligence, lack of industrial clusters accumulated and led by leading enterprises. The transformation and upgrading of traditional industries is arduous, and the innovation ecology needs to be strengthened and improved. Digital twin technology is one of the most important technological development trends in the world today. At present, countries all over the world attach great importance to the development of digital twin technology. The deep integration of digital twin technology and manufacturing industry will deeply empower enterprises to innovate and develop, and enhance the development momentum, potential and potential energy, so as to lead and promote the significant improvement of enterprise innovation ability, industrial innovation energy efficiency and urban innovation level. To build "academies" and draw "lines" to enhance the innovation ability of enterprises, first of all, support enterprises to create high-level research and development institutes, and use them to coordinate innovation resources to promote the construction of enterprise innovation system and innovation activities. High-level, multi-level and wide-ranging enterprise digital innovation platform system is the basis and condition for manufacturing enterprises to carry out product digital twins, production digital twins and equipment operation digital twins, reduce enterprise operating costs and enhance market competitiveness. Guangzhou's leading enterprises should be strongly encouraged to build a digital scientific and technological innovation platform with the construction objectives of national key laboratory, national engineering laboratory, national enterprise technology center, and national industrial design center, and to create an enterprise research and development institute with three innovative modules, which are comprehensive, operational and functional, and are interdependent and mutually reinforcing, Give full play to the strategic, overall and supportive role of the Enterprise Research and Development Institute in the construction of the urban innovation system, the integrated innovation of enterprise digital products (IPD) and the product life cycle management, and enhance the enterprise's digital twin innovation capability. Secondly, enterprises are encouraged to draw a high-quality enterprise innovation roadmap and lead the development of enterprises. The enterprise innovation roadmap is an action plan formulated by an enterprise to achieve its development goals, including the ideological route, technical route, product route, market route and organizational route. The establishment of a roadmap for enterprise digital innovation with clear objectives, forward-looking guidance, scientific and reasonable measures and strong measures will provide an important action guide for enterprises to aim at the forefront of world science and technology, connect external resources, unify leadership ideas, guide staff practice. We should vigorously promote Guangzhou manufacturing enterprises to carry out technology foresight and develop enterprise innovation roadmap, so as to continuously refine the direction of scientific and technological development, improve the digital twin innovation mechanism, stimulate innovation vitality, and guide enterprises to develop with high quality. Thirdly, establish a mechanism to encourage and guide enterprises to build "academies" and draw "lines", promote enterprises to carry out relevant work, and promote the experience of benchmarking enterprises. A group of excellent enterprises in Guangzhou