(The staff of the Biological Island Laboratory are doing experiments.) A new scientific research institution without administrative level and fixed staffing has successfully achieved the strategic goal of establishing a national laboratory. How does this innovation practice happen? Recently, the Bio Island Laboratory (formerly known as the Guangzhou Regenerative Medicine and Health Guangdong Provincial Laboratory) told about the "entrepreneurship experience" in the past five years. On December 22, 2017, the Bio Island Laboratory was officially established under the license of the provincial government. It is a provincial registration institution, and is one of the first four provincial laboratories to be launched by the Guangdong benchmarking national laboratory. At the beginning of its birth, the Bio Island Laboratory has been carrying the expectation of "strengthening the national strategic scientific and technological strength". By deeply cultivating the "experimental field" of scientific research system and mechanism reform, the Bio Island Laboratory has stimulated and released innovative creativity to the maximum extent, and has made fruitful achievements in scientific research tasks, talent introduction and cultivation, platform construction, epidemic tackling and other aspects, and delivered a satisfactory five-year answer sheet. The two laboratories "connected by blood" only took 35 days. Wu Guangming, the project leader and researcher of Bio Island Laboratory, led the research team to successfully construct humanized mice expressing human COVID-19 receptor ACE2. Normally, it will take at least half a year to complete such work. "COVID-19 is very cunning. Most human infected people are asymptomatic or mild at first, which is more obvious in mice." Wu Guangming said that at the beginning of the epidemic, the time window for researchers to carry out drug screening, vaccine development and other work with mice was very short. Through urgent and unremitting efforts, the Bioisland laboratory team tried to build a mouse model of premature aging or with hypertension, diabetes, immunodeficiency and other characteristics through gene editing, providing a significant reference for precise drug screening and severe treatment. Taking this as a microcosm, since the outbreak of the COVID-19, the Bio Island Laboratory has responded to national needs with scientific research achievements, established an integrated epidemic prevention and control system of "prevention, detection and treatment", and implemented multiple "wartime" scientific research projects. A large number of achievements, such as COVID-19 IgM antibody rapid detection kit, AI auxiliary diagnosis system, and new usage of chloroquine phosphate, have been used in the front line of epidemic resistance. Now, the relevant teams of Bio Island Laboratory involved in tackling epidemic problems have been transferred to Guangzhou Laboratory. Wang Huisheng, assistant director of the Guangzhou Laboratory, introduced that the Guangzhou Laboratory will continue to tackle key problems in basic research, prediction and early warning, rapid detection products, innovative drug vaccine research and development, and provide important scientific and technological support for the prevention and control of COVID-19 epidemic in China and the world. "The two laboratories are connected by blood and like brothers." Wang Huisheng said that the Bio Island Laboratory is the main preparation unit and the supporting unit for the physical operation of the Guangzhou Laboratory, providing a solid foundation for the preparation and efficient operation of the Guangzhou Laboratory. In terms of talents, sites, equipment and other aspects, the Bio Island Laboratory provides transportation, support and support to Guangzhou Laboratory. For example, the former provides newly renovated scientific research sites and newly constructed scientific research platforms to the latter for use. During the anti epidemic period, the bio island laboratory ushered in the "golden period" of construction and development, which not only won the honor of the national advanced anti epidemic collective of science and technology system, but also helped to promote the creation of the national laboratory. In the future, Bio Island Laboratory will