Professor Zhao Gang, School of Information Science and Technology, University of Science and Technology of China, cooperated with Professor Shi Qinghua, School of Life Sciences, and Professor Cao Yunxia, Reproductive Medicine Center of the First Affiliated Hospital of Anhui Medical University, and successfully achieved high-quality cryopreservation of mouse follicles through the synergistic ice suppression effect based on structural bionics and space physical field. Relevant research results have been published in Nature Communication. According to the reviewers, this is "a potential fertility preservation method" and "opens up a new way to restore human fertility". At present, how to better preserve female fertility is a major health issue of common concern to all mankind. Because follicles are rich in sources, easy to obtain and do not involve too many ethical issues, their cryopreservation is an important supplement to cryopreservation of oocytes, embryos and ovarian tissues; In addition, follicular preservation is almost the only way to preserve the fertility of underage women and unmarried women with cancer. The existing methods for cryopreservation of follicles, due to the high concentration and toxicity of cryoprotectant, lead to tedious operation and poor preservation effect. To this end, the low-temperature biomedical research team of the University of Science and Technology of China developed a vitrification preservation method of mouse follicles with low concentration cryoprotectant based on the cooperative ice suppression strategy. They combined magnetothermal and photothermal space rewarming with hydrogel microencapsulation to achieve cooperative ice suppression and reduce the concentration of permeable protectant by 75%. This method has the advantages of low concentration and low toxicity of cryoprotectant required by the traditional programmed cooling and freezing method, as well as the advantages of convenient operation of the traditional vitrification cooling process. In the study, the survival rate of follicles preserved by this method increased by about 30% after cryopreservation and resuscitation. After 3D culture in vitro, mature oocytes can be successfully discharged. The oocytes can be further fertilized in vitro and transplanted into the surrogate mice to give birth to healthy offspring. In addition, this study also established an integrated platform integrating microencapsulation, freezing, rewarming and 3D culture, providing a unique solution for the preservation and full utilization of follicles. (Outlook New Times)