On the morning of November 1, on the live broadcast of the 2022 Shenzhen Global Innovation Talent Forum, Yan Ning, a famous scientist, announced that he would resign from Princeton University and join the Shenzhen Academy of Medical Sciences. "In the near future, I will return home full time to assist Shenzhen in creating a new research and development institution that integrates scientific research, transformation, student training, funding and other functions. This is the Shenzhen Medical Academy of Research and Translation (SMART) for short." Yan Ning said. In May 2017, Yan Ning accepted the invitation of Princeton University and was employed as Shirley Tillman Lifetime Chair Professor of Molecular Biology Department of Princeton University; In 2019, he was elected as a foreign academician of the National Academy of Sciences of the United States; In 2021, he was elected as a foreign academician of the American Academy of Arts and Sciences. Yan Ning said that teaching at Tsinghua and Princeton is her first two dreams in life, and she will strive to realize the third dream in Shenzhen. In her speech, she expressed the hope that with the joint efforts of several generations, Shenzhen would play an important role in the world's biomedical landscape in 10 or 20 years. The Shenzhen Academy of Medical Sciences, which carries Yan Ning's third dream, was established by the Shenzhen Municipal Government and registered as a public institution run by the Shenzhen Municipal Government. It implements the president responsibility system under the leadership of the Party Committee, with variable staffing and levels, and implements a socialized employment system. As the legal representative of Shenzhen Academy of Medical Sciences, the President is recruited globally and appointed by the Council. The tenure system is implemented. According to the Construction Plan of Shenzhen Academy of Medical Sciences (hereinafter referred to as the "Plan") issued by the Shenzhen Municipal Government Gazette, the basic principles of the construction of Shenzhen Academy of Medical Sciences are health first, focus on the frontier, co build and share, first try, and run the academy according to law. It will focus on solving major scientific and key technical problems "centering on health", and actively layout key fields and key technologies of medical science and technology, It mainly builds an integrated medical science and technology collaborative innovation platform, an open medical science and technology resource management platform, a leading medical science and technology foundation support platform, an innovative medical science and technology talent training platform, and a smart medical science and technology strategic research think tank. According to the Plan, Shenzhen Academy of Medical Sciences will explore six innovative mechanisms, namely, flexible talent introduction and employment mechanism, linkage multi-dimensional cooperation mechanism, diversified funding mechanism, innovative research funding mechanism, scientific evaluation mechanism, and collaborative industrial transformation mechanism. The Plan also proposes that the development goal of Shenzhen Academy of Medical Sciences is that by 2025, the Shenzhen Medical Science and Technology Collaborative Innovation Community, with the Shenzhen Academy of Medical Sciences as the hub and bridge, will be basically completed, research in some key areas will make progress, and the prevention and treatment technology for key populations and major diseases will achieve a phased breakthrough; By 2035, we will form replicable and replicable experience in the construction of medical science and technology innovation system, institutional arrangements, and rule docking; By the middle of this century, the Shenzhen Academy of Medical Sciences had become a world-famous medical research institution, and the Guangdong Hong Kong Macao Greater Bay Area had outstanding competitiveness, innovation and influence in medical science. (Liu Xinshe)