"Can't lie down smoothly", "Once the disease relapsed to the point of going out in a wheelchair", "There was a petrified feeling"... Recently, Li Yuchun introduced her new song "Five Zangs and Six Viscera" in the second season of "My Bronze Age", which was created by her from the first perspective of ankylosing spondylitis patients, and the heated discussion caused by it is also expanding from the song itself to the medical circle. It is understood that ankylosing spondylitis is a chronic inflammatory disease mainly involving the axial joint. As one of the drugs to treat this disease, the original drug Xiumelo (Adalimumab) is known as the "king of medicine" because of its high sales. Before Xiumeile was included in the medical insurance, the annual treatment cost of patients was close to 200000 yuan. After entering medical insurance in 2019, the annual treatment cost of drugs will be reduced to about 30000 yuan. With the coming into the market of domestic adalimumab drugs, the drug burden of patients is further reduced. Gao Fa admitted in the second season of "My Bronze Age" a few days ago that he suffered from ankylosing spondylitis and felt "petrified" when serious. Ankylosing spondylitis is a general term for a group of chronic inflammatory diseases, mainly characterized by sacroiliac joint and spinal column involvement, and can also involve peripheral joints or extraarticular tissues and organs. 20-40 years old is the main age group of ankylosing spondylitis patients. Although the overall prevalence of ankylosing spondylitis is relatively low, about 0.3%, more than 3 million patients in China are suffering from this disease. In addition to Li Yuchun, it is also reported that celebrities including Jay Chou, Zhang Jiayi and Cai Shaofen also suffer from ankylosing spondylitis. It is understood that the etiology of ankylosing spondylitis is still unclear, but it is currently believed to be related to genetics, infection, environment, immunity and other factors. Professor Zhang Xuewu, chief physician of the Rheumatology and Immunization Department of Peking University People's Hospital, said that the early symptoms of ankylosing spondylitis were not very typical, but there were still ways to identify the "characteristics" of the pain, when the unexplained low back pain lasted for 3 months or more; The pain increases at night, and may wake up in the middle of the night if it is serious; When you wake up in the morning, your back is stiff (morning stiffness). Exercise can relieve pain and other symptoms. Be careful of ankylosing spondylitis. Zhang Xuewu introduced that ankylosing spondylitis has a certain family aggregation tendency, which is mainly related to HLA-B27 gene. In order to find the lesions earlier, MRI+gene examination+back pain symptoms (including extraarticular symptoms) are the main diagnostic basis in clinical practice. It is impossible to cure the disease as early as possible. Because of its high recurrence rate, ankylosing spondylitis is also known as "immortal cancer". At present, ankylosing spondylitis mainly controls symptoms and delays disease progress through drug treatment. "Ankylosing spondylitis has no radical treatment methods and drugs, and what is advocated at present is standard treatment." Zhang Xuewu said that the early treatment of ankylosing spondylitis was mainly NSAIDs, which were mainly used to diminish inflammation and relieve pain, but could not prevent the development of ankylosing spinal disease. The appearance of biological agents controls the development of inflammation to a certain extent. The earliest biological agent is called tumor necrosis factor (TNF- α) Antagonists. In recent years, a new class of interleukin-17A (IL-17A) inhibitors has emerged, which can control inflammation and relieve symptoms,