A new study was announced at the 2022 American Heart Association (AHA) hypertension conference held on the 7th local time. When hypertension was induced in young mice, their bone loss and osteoporosis related bone damage were comparable to those of old mice. This finding may help researchers to identify immune cells and mechanisms that play a role in human bone health, and bring new methods to prevent osteoporosis in early adulthood. In the experiment, researchers compared young mice with induced hypertension and old mice without hypertension to evaluate the potential relationship between hypertension and bone aging. Elizabeth Maria Henning, the lead author of the study and a doctoral candidate in biomedical engineering at Vanderbilt University in Nashville, said that the human age of young mice is equivalent to 20-30 years old, while the human age of older mice is about 47-56 years old. A group of 12 young mice (4 months old) were injected with angiotensin II, a hormone that causes hypertension. Young mice received 490 ng / kg angiotensin II for 6 weeks. A group of 11 older mice (16 months old) also received 490 ng / kg angiotensin II for 6 weeks. Two control groups consisting of 13 young mice and 9 old mice received buffer solution excluding angiotensin II, and these mice did not develop hypertension. After 6 weeks, the researchers analyzed the bones of all 4 groups of mice. The health of bone depends on the strength and density of bone. Mathematical algorithms were used to evaluate the potential effects of hypertension and aging on the bone microstructure and strength of mice. Compared with young mice without hypertension, the bone volume fraction of young mice with induced hypertension was significantly reduced by 24%, the thickness of sponge bone (such as femur and spine) at the end of long bone was reduced by 18%, and the ability of bone to withstand different types of forces was estimated to be reduced by 34%. This will make the bones weaker and lead to spinal fractures in later life. In contrast, elderly mice receiving angiotensin II infusion did not show similar bone loss. (outlook new era)