Nucleic acid detection is a "monitoring network" for epidemic prevention and control. It is one of the most important means to quickly find people infected with the virus, effectively cut off the route of transmission and prevent the spread of the epidemic. Recently, such information can be seen in wechat groups or circles of friends, "wash your mouth and drink water before making nucleic acid, otherwise you will have a false positive." "After drinking, you should drink enough water and rinse your mouth before you can check nucleic acid" and so on. In this regard, Guo Wei, deputy chief physician of the National Medical Center for major public health events and the infection department of Tongji Hospital, answered that drinking water or eating before nucleic acid detection of oropharyngeal swabs will dilute the virus attached to the pharynx, especially drinking hot water will inhibit the activity of the virus. In order to improve the accuracy of nucleic acid detection of pharyngeal swab, it is recommended that the subjects do not drink water, drink alcohol or chew gum 30 minutes before the detection, so as to ensure the high accuracy of nucleic acid detection of pharyngeal swab. In addition, in order to prevent reflex vomiting stimulated by pharyngeal swab, avoid eating 2 hours before sampling. At the same time, we remind you to pay attention to the following points during nucleic acid detection: First, when queuing for nucleic acid sampling, please do not crowd and pile up, abide by the "one meter line" principle, and do not talk and chat loudly. Second, during nucleic acid sampling, the head should be slightly tilted and relaxed, the mouth should be wide open, and the mouth should be "ah", but it is not recommended to make "ah" sound and hold your breath at the same time, so as to reduce the risk of infection. Third, when a current tester has completed the detection, do not come forward immediately. You can wait for the medical staff to make preparations for the next acquisition tool, and then take off the mask after making a gesture, cooperate with the instruction to complete the detection as soon as possible, then quickly put on the mask and leave the sampling point. Fourth, when collecting nucleic acids, do not touch the sampling desktop with your hands, and do not put personal items such as mobile phones and ID cards on the desktop. (outlook new era)