Recently, the topic # HPV vaccine can only be injected once for three injections # has been on the hot search, which has attracted the attention of many people who are fighting for vaccines or are planning to start vaccination. From April 4 to April 7, 2022, who said on its official website that "one shot of human papillomavirus (HPV) vaccine can effectively prevent cervical cancer, and the protection effect is equivalent to that of two or three shots of vaccine." According to the specific contents released by who, the recommended HPV vaccination dose plan is as follows: girls aged 9-14 (the main population) can be vaccinated once or twice; Young women aged 15-20 were vaccinated once or twice; Women over 21 years old were injected twice (6 months apart); Immunocompromised individuals, including those infected with HIV, should be vaccinated three times if feasible, otherwise at least two times. The who's proposal is actually to solve the problem of low global coverage of HPV vaccine and to enable 90% of girls to be vaccinated before the age of 15 by 2030. At the same time, it can also relieve the global supply pressure. So, can one shot of HPV vaccine really replace three shots? In addition to vaccination, what are the methods to prevent cervical cancer? Let's see. What is cervical cancer? Cervical cancer is the second most common malignant tumor in gynecology, and its incidence rate is second only to breast cancer. The high incidence age is 50-55 years old, but in recent years, there has been a trend of gradual rejuvenation, and more and more cases of onset before 30 years old. Although the mortality rate of cervical cancer is very high, it is the only disease with definite etiology in malignant tumors that can be prevented and screened early. What is the relationship between HPV and cervical cancer? HPV is a human papillomavirus, which can cause the proliferation of human skin mucosa. More than 96% of cervical cancer patients are infected with HPV. At present, more than 200 different subtypes of HPV virus have been isolated. According to the risk, the subtype with high carcinogenic risk is called high-risk type, and the subtype with low carcinogenic risk is called low-risk type. Low risk HPV virus can cause flat warts, condyloma acuminatum and other diseases. High risk viruses can cause cervical cancer in women, penile cancer, anal cancer and prostate cancer in men. The most common are high-risk HPV-16 and hv-18, accounting for more than 87% of the total cervical cancer. Therefore, if you are infected with HPV 16 and HPV 18, you must attach great importance to it. German virologist Harald zur hausen was the first to find a clear causal relationship between HPV and cervical cancer, and laid the foundation for cervical cancer vaccine, making cervical cancer a truly preventable disease. High risk group of cervical cancer? The main way of HPV infection is sexual transmission, so people who have sex earlier and have more sexual partners have a greater chance of infection; In most cases, HPV can be cleared by human immunity and self-healing, but people with low immune function will be repeatedly infected or cause cancer; People with a family history of cervical cancer, endometrial cancer, vaginal cancer or vulvar cancer have a higher incidence of the disease. For sexual