"Rational use of antibiotics and vigilance against drug risks." Recently, the State Food and Drug Administration issued a document to remind all patient friends that please follow the principle of antibiotic use. If you can use narrow-spectrum antibiotics, do not use broad-spectrum antibiotics, if you can use low-level antibiotics, do not use high-level antibiotics, and if you can use one to solve problems, do not use two. At the same time, it should be noted that the efficacy of antibiotics has a cycle, and the necessary cycle should be taken under the guidance of doctors. It is reported that anti infective drugs refer to drugs that can kill or inhibit various pathogenic microorganisms, including antibiotics, synthetic antibiotics and antiviral drugs. They are widely used in clinic and are the focus of national adverse drug reaction monitoring. Among them, antibiotics are only applicable to inflammation caused by bacteria and some other microorganisms, but not to inflammation caused by viruses. The common adverse reactions of antibiotics include allergic reaction, toxic reaction, double infection, drug resistance and so on. The elderly, infants, the infirm, those undergoing abdominal surgery and those abusing antibiotics are more prone to double infection, which is generally difficult to control and has great risk. Most bacteria can be resistant to antibiotics, and the abuse of antibiotics will lead to the increasing number of drug-resistant strains and affect the treatment of diseases. In addition, according to the annual report of national adverse drug reaction monitoring (2021) released by the national adverse drug reaction monitoring center on March 30, the proportion of adverse drug reaction / event reports of anti infective drugs in the overall report has continued to decline in recent years, indicating that the national measures to strengthen the use and management of anti infective drugs have achieved certain results, but the number of serious adverse reaction reports is still high, It is suggested that the risk of anti infective drugs still needs to be paid more attention. The report shows that the top 3 drugs in 2021 were the cephalosporins, quinolones and macrolides. The top 3 of the most serious adverse events / reports were cephalosporins, quinolones and anti tuberculosis drugs. In the report of adverse reactions / events of anti infective drugs in 2021, injections accounted for 76.3%, oral preparations accounted for 19.8%, and other dosage forms accounted for 3.9%; Compared with the overall reported dosage form distribution of drugs, the proportion of injections is high. In the reports of serious adverse reactions / events, injections accounted for 78.6%, oral preparations accounted for 20.1%, and other dosage forms accounted for 1.3%. (outlook new era)