On December 4, the world's first dual carrier 13 valent pneumonia vaccine was officially launched in Guangzhou. The vaccine combines two carrier proteins (tetanus toxoid / diphtheria toxoid) with pneumococcal capsular polysaccharide and is developed by Beijing minhai biology, a wholly-owned subsidiary of Guangdong enterprise Kangtai Biological Products Co., Ltd. This is also the second domestic and the third globally approved 13 valent pneumonia vaccine. Coccal pneumonia is an important cause of death in children under 5 years old. Its drug resistance is increasing in recent years. Zheng Huizhen, chief physician of Guangdong CDC, introduced that the immune function of children under the age of 5 has not been fully developed. Once infected with coccal pneumonia, it is very likely to cause serious sequelae such as mental retardation and paralysis. "13 valent pneumonia vaccine can protect children from 13 pathogenic serotypes of pneumococci and help children establish a protective barrier." "The 13 valent pneumonia vaccine adopts double carriers, which can avoid the competition of single carrier protein and the inhibitory effect of helper T cells on polysaccharide immune response," said Zheng Jingshan, vice president of Guangdong Preventive Medicine Association. According to the phase III clinical trial data of 13 valent pneumonia vaccine, the antibody positive rate and geometric average titer against 13 pneumococcal serotypes are not inferior to similar imported products. Meanwhile, in clinical trials, the incidence of adverse reactions of the vaccine was lower than that of the control group. "The 13 valent pneumonia vaccine has an effect on infants and children aged from 6 weeks to 5 years (before the 6th Birthday). Compared with similar vaccines in the past, the time limit for vaccination has been relaxed." Zhao Chang'an, director of emergency pediatrics of Guangdong maternal and child health hospital, said that in winter, children in closed areas such as kindergartens are dense, and the risk of cross infection is high. Vaccination and prevention should be done in advance, It is particularly necessary. (outlook new era)