The Nanotechnology Research Institute team at the University of Sydney in Australia has successfully developed a custom designed and programmable nanorobot using DNA origami technology. This innovative achievement demonstrates a wide range of application prospects, covering multiple fields such as targeted drug delivery, responsive materials, and energy-saving optical signal processing. The results were published in the journal Science Robotics on the 27th. DNA origami technology is based on the folding characteristics of DNA molecules themselves, and through careful design, can construct completely new biological structures. The research team has created over 50 nanoscale object models, including a "nanodinosaur", a "dancing robot", and a miniature map of Australia with a width of only 150 nanometers. This study specifically focuses on how to construct modular DNA origami "voxels" (similar to pixels in three-dimensional space) to assemble into more complex three-dimensional structures. These structures can be programmed and adjusted according to specific needs to quickly generate prototypes in various forms. This feature is particularly important for developing nanoscale robotic systems capable of completing research tasks in synthetic biology, nanomedicine, and materials science. The team achieved precise regulation of voxel binding by introducing additional DNA strands onto the surface of the nanostructure as programmable connection points. These connection points are like colored nylon buckles, which can only be connected to each other when the "color" (i.e. DNA sequence) matches, ensuring the accuracy and specificity of the structure during the construction process. One important application of this technology is to manufacture nanorobots that can accurately deliver drugs to specific areas within the body. With the help of DNA origami technology, scientists can design nanocarriers that are sensitive to specific biological signals, ensuring that drugs are released at predetermined times and locations, greatly improving treatment efficacy while reducing side effects. In addition, the team is also exploring the development of new materials that can respond to external stimuli. This type of material can adjust its properties based on factors such as load changes, temperature, or acidity/alkalinity, and is expected to affect multiple industries such as healthcare, computing, and electronics. (New Society)
Edit：Yao jue Responsible editor：Xie Tunan
Source：Science and Technology Daily
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