On the 16th, it was learned from Xuanwu Hospital of Capital Medical University that Professor Wu Liyong's team and Professor Dong Xiaoping's team from the Chinese Center for Disease Control and Prevention have published research papers in the well-known journal "Journal of the American Medical Association: Neurology". This achievement is the first large-scale study internationally to evaluate the important value of real-time vibration induced transformation (RT QuIC) technology in the diagnosis of prion diseases, providing a basis for early diagnosis of prion diseases. Prion protein disease is a lethal neurodegenerative disease, in which patients typically experience symptoms such as memory loss, mental abnormalities, and motor disorders in a short period of time, ultimately leading to death. Due to the lack of specificity in the early symptoms of prion diseases and the low sensitivity of conventional examination methods, prion diseases are easily confused with other neurological diseases, leading to misdiagnosis. The latest research suggests that skin RT QuIC technology detection may have higher sensitivity than cerebrospinal fluid, but the related findings lack validation from large-scale in vivo skin studies. This study included 101 patients with prion diseases and 23 patients without prion diseases from Xuanwu Hospital. The research team collected samples from patients' areas including behind the ear, upper arm, lower back, and inner thigh, as well as cerebrospinal fluid samples from 94 patients. The results showed that under three dilution conditions, the sensitivity of RT QuIC technology in different skin areas was 84.9% behind the ear, 80.0% in the upper arm, 83.7% in the lower back, and 84.8% in the inner thigh. The study also found that in multi site combination testing, the sensitivity of combining any two skin samples can reach 92.1%, significantly higher than the sensitivity of testing cerebrospinal fluid alone (75.5%). When combining all skin samples, the sensitivity was further increased to 95%, fully demonstrating the advantages of multi site skin testing in the diagnosis of prion diseases. (New Society)
Edit：Chen Jie Responsible editor：Li Ling
Source：Science and Technology Daily
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