According to the official website of the Langley Health Center at New York University on the 24th, surgeons at the center performed the first combined surgery of a mechanical heart pump (LVAD) and a gene edited pig kidney transplant. This surgery represents the fusion of multiple medical advancements, showcasing the possibilities and hopes of modern medicine. There have been no records of people using mechanical heart pumps receiving any type of organ transplantation before, and transplanting genetically edited pig kidneys into living humans is the second time, but the first time it binds to the thymus. Before the surgery, 54 year old female patient Lisa Pisano suffered from heart failure and end-stage kidney disease. If there was no heart pump, heart failure would leave Pisano's life expectancy with only a few days or weeks left; Her kidney disease requires dialysis, and during the dialysis period, she does not meet the conditions for using a heart pump; The antibody reaction made it impossible for her to undergo traditional kidney transplantation. Researchers say that treating it is like being in a maze, unable to find a way out, until they decide on a plan for a pig kidney transplant. This time, the doctor completed this feat in two stages. In the first surgery performed on April 4th, the doctor implanted a heart pump into Pisano. The second surgery was a xenograft. On April 12th, the team transplanted her genetically edited pig kidney and thymus to help resist rejection. The research team genetically engineered pigs, responsible for disrupting or "knocking out" them to produce α- The gene of gal. Previous research at the University of New York at Langley has shown that removing α- Gal can prevent antibody reactions, which may lead to fatal hyperacute rejection of xenografts. The previously transplanted donor pig thymus is responsible for educating the immune system by surgically placing it under the renal cover to reduce the possibility of rejection. Researchers suggest that by using pigs modified with a single gene, doctors can better understand the role of a key stable change in the genome in the success of xenotransplantation. As these pigs can reproduce, there is no need for more complex cloning, which is a sustainable and scalable solution to address organ shortages. This is the world's first LVAD surgery performed on dialysis patients, followed by kidney transplantation. The team believes that the measure of success is that patients have the opportunity to achieve a better quality of life and have more time to spend with their families. 【 Circle 】 Pisano can be said to be the most difficult patient a doctor has ever seen: she already has high levels of harmful antibodies to human tissues, and if she is waiting for a human kidney transplant, it will take many years to find a matching partner. But without a kidney transplant, she would use a heart pump and also undergo dialysis, resulting in a very high mortality rate. Fortunately, the medical team has found the path of pig kidney transplantation. After this series of surgeries, she is now able to perform some activities with a walking aid. Her husband said, "I see my wife's smile again." This is the biggest reward for the medical team. (Lai Xin She)
Edit：GuoGuo Responsible editor：FangZhiYou
Source：People.cn
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