According to the new issue of Nature Nanotechnology, a research team from the Catalan Institute of Biotechnology in Spain successfully reduced the volume of mouse bladder tumors by 90% using a single dose urea driven nanorobot. Although the current treatment method of directly administering drugs to the bladder has shown good survival rates, its treatment efficiency is still very low. A promising alternative is to use nanoparticles that can directly deliver therapeutic agents to tumors, especially nanoparticles (nanorobots) that can self propel within the human body. The newly developed nanorobot is composed of porous spheres made of silica. Their surfaces contain various components with specific functions. This includes urease, a protein that can react with urea in urine, allowing nanoparticles to self propel. Another key component is radioactive iodine, which is commonly used for local treatment of tumors. Researchers say that the new method can reduce tumor volume by 90% with a single dose. This method is not only efficient, but also reduces patient hospitalization time and treatment costs. New research has demonstrated the migration rate of nanoparticles in the bladder and their accumulation in tumors. The innovative optical system developed by researchers can eliminate the light reflected by the tumor itself, identify and locate nanoparticles of the entire organ with unprecedented resolution without the need for prior labeling. Research has observed that nanorobots can not only reach tumors, but also enter tumors, thereby enhancing the effectiveness of radiopharmaceuticals. These nanorobots can decompose the extracellular matrix of tumors by locally increasing pH through self propulsion chemical reactions. This is conducive to more efficient tumor infiltration and facilitates preferential accumulation in tumors. Reporter: Zhang Mengran
Edit：GuoGuo Responsible editor：FangZhiYou
Source：people.cn
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