On January 8, the reporter learned from the Southwest Hospital of the Army Military Medical University that Zhang Yi's team, the director of breast surgery of the hospital, and Wu Guangyan's team, the doctor of the Army Military Medical University, first revealed the central nervous circuit mechanism that anxiety accelerates the development of breast cancer, providing a key theoretical basis for studying how anxiety affects the development of breast cancer from the perspective of neural regulation, and providing new strategies and programs for treatment and intervention of breast cancer. The relevant research results have been published in the international medical journal Clinical Research Journal. "Breast cancer has become one of the malignant tumors with a high incidence rate in the world, which seriously endangers women's health." Zhang Yi said that in his daily diagnosis, many patients suffering from breast cancer quickly deteriorate due to excessive anxiety. Clinical studies have also found that emotional abnormalities can accelerate the development of tumors and worsen the condition. In order to clarify the relationship between the development of breast cancer and emotion, Zhang Yi's team used mice suffering from breast cancer as models to explore the impact of emotion on cancer patients. During the experiment, the team found that the development of breast cancer in mice was significantly accelerated after increasing the anxiety of mice by activating the brain nerve nucleus in charge of anxiety in the mouse brain through photo genetic and chemical genetic technology; Conversely, the use of drugs to reduce anxiety in mice can inhibit the development of breast cancer in mice. Wu Guangyan introduced that after multiple experiments, the research team has concluded that anti anxiety drugs can inhibit the activity of the sympathetic nervous system by inhibiting the central emotion related neural circuit, reducing the amount of norepinephrine acting on tumor cells or the tumor microenvironment, thereby slowing down the development process of breast tumors. "This research achievement reveals the mechanism of breast cancer development from the perspective of brain tumor interaction, and provides a new perspective and direction for tumor treatment." Zhang Yi said that this research is not only important for the treatment of cancer patients, but also helps to enhance the public's awareness and understanding of the relationship between breast cancer and emotion. In addition, the study also provides scientific basis for the application of anti anxiety drugs in cancer treatment. "We hope to remind doctors and patients through this study that when facing major diseases such as cancer, in addition to paying attention to the patient's physical condition, we also need to pay attention to the patient's emotional state. Improving patients' anxiety, fear and other negative emotions through medication or psychological adjustment may improve treatment effectiveness and achieve better prognosis," said Zhang Yi, The future research team will continue to delve into the role and mechanisms of the nervous system in tumor regulation, exploring the relationship between neural regulation and existing targeted therapies and immunotherapies. On the other hand, further drug trials will be conducted in clinical practice to explore various combination therapy options. (Lixin News Agency) (Reporter Yong Li, Correspondent Huang Qiao)
Edit：GuoGuo Responsible editor：FangZhiYou
Source：people.cn
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